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BrnT family toxin
BrnT is a ribonuclease toxin of a type II toxin-antitoxin system that exhibits a RelE-like fold. The antitoxin that neutralises this toxin is Pfam:PF14384. BrnT is found in bacteria, archaea, bacteriophage, and plasmids. BrnT-BrnA forms a 2:2 tetrameric complex and autoregulates its own expression, which is induced by a number of different environmental stresses. Expression of BrnT alone results in cessation of bacterial growth which can be rescued after subsequent expression of BrnA [1]. [1]. 22334680. Molecular structure and function of the novel BrnT/BrnA. toxin-antitoxin system of Brucella abortus.. Heaton BE, Herrou J, Blackwell AE, Wysocki VH, Crosson S;. J Biol Chem. 2012;287:12098-12110. (from Pfam)
BrnT family toxin is the ribonuclease toxin component of a type II toxin-antitoxin (TA) system, similar to Brucella abortus BrnT that adopts a RelE-like fold
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