Protein Family Models

This domain is found in a variety of transcriptional regulatory proteins. It is related to bacterial periplasmic binding proteins, although this domain is unlikely to be found in the periplasm. This domain acts as a sensor binding small molecule ligands that the DNA-binding domain responds to. This domain recognises Sugars, sugar phosphates, sugar acids and purines (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). (from Pfam)

Date:

2024-08-14

Date:

2024-08-14

This family includes the periplasmic binding proteins, and the LacI family transcriptional regulators. The periplasmic binding proteins are the primary receptors for chemotaxis and transport of many sugar based solutes. The LacI family of proteins consist of transcriptional regulators related to the lac repressor. In this case, generally the sugar binding domain binds a sugar which changes the DNA binding activity of the repressor domain (Pfam:PF00356). [1]. 1583688. 1.7 A X-ray structure of the periplasmic ribose receptor from. Escherichia coli.. Mowbray SL, Cole LB;. J Mol Biol 1992;225:155-175.. [2]. 8638105. Crystal structure of the lactose operon repressor and its. complexes with DNA and inducer.. Lewis M, Chang G, Horton NC, Kercher MA, Pace HC, Schumacher MA,. Brennan RG, Lu P;. Science 1996;271:1247-1254. (from Pfam)

Date:

2024-08-14

LacI family DNA-binding transcriptional regulator functions as an activator or repressor by binding a specific effector ligand that either decreases (induction) or increases DNA-binding affinity (co-repression); similar to Escherichia coli HTH-type transcriptional regulator IdnR

Date:

2023-03-09