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AMP-binding enzyme C-terminal domain
This is a small domain that is found C terminal to Pfam:PF00501. It has a central beta sheet core that is flanked by alpha helices. (from Pfam)
AMP-binding protein
chorismate-binding protein
This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase. [1]. 11371633. The structures of anthranilate synthase of Serratia marcescens. crystallized in the presence of (i) its substrates, chorismate. and glutamine, and a product, glutamate, and (ii) its. end-product inhibitor, L-tryptophan.. Spraggon G, Kim C, Nguyen-Huu X, Yee MC, Yanofsky C, Mills SE;. Proc Natl Acad Sci U S A 2001;98:6021-6026.. [2]. 11450855. A metabolic node in action: chorismate-utilizing enzymes in. microorganisms.. Dosselaere F, Vanderleyden J;. Crit Rev Microbiol 2001;27:75-131. (from Pfam)
salicylate synthase
Members of this protein family are salicylate synthases, bifunctional enzymes that make salicylate, in two steps, from chorismate. Members are homologous to anthranilate synthase component I from Trp biosynthesis. Members typically are found in gene regions associated with siderophore or other secondary metabolite biosynthesis. Examples with context-specific names include MbtI from mycobactin biosynthesis, YbtS (Irp9) from yersiniabactin biosynthesis, and NbtS from nocobactin NA biosynthesis pathways.
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