Protein Family Models

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2024-08-14

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2024-08-14

This entry represents a wide variety of bacterial Ig domains. [1]. 21606337. Structure of a bacterial cell surface decaheme electron conduit.. Clarke TA, Edwards MJ, Gates AJ, Hall A, White GF, Bradley J,. Reardon CL, Shi L, Beliaev AS, Marshall MJ, Wang Z, Watmough NJ,. Fredrickson JK, Zachara JM, Butt JN, Richardson DJ;. Proc Natl Acad Sci U S A. 2011;108:9384-9389. (from Pfam)

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2024-08-14

This domain is found in a number of bacterial chitinases and similar viral proteins. It is organised into a fibronectin III module domain-like fold, comprising only beta strands. Its function is not known, but it may be involved in interaction with the enzyme substrate, chitin [1,2]. It is separated by a hinge region from the catalytic domain (Pfam:PF00704); this hinge region is probably mobile, allowing the N-terminal domain to have different relative positions in solution [1]. [1]. 7704527. Crystal structure of a bacterial chitinase at 2.3 A resolution.. Perrakis A, Tews I, Dauter Z, Oppenheim AB, Chet I, Wilson KS,. Vorgias CE;. Structure 1994;2:1169-1180.. [2]. 9377712. Evolution of immunoglobulin-like modules in chitinases: their. structural flexibility and functional implications.. Perrakis A, Ouzounis C, Wilson KS;. Fold Des 1997;2:291-294. (from Pfam)

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2024-08-14

The REJ (Receptor for Egg Jelly) domain is found in PKD1 Swiss:P98161, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains. [1]. 8666666. The sea urchin sperm receptor for egg jelly is a modular protein. with extensive homology to the human polycystic kidney disease. protein, PKD1.. Moy GW, Mendoza LM, Schulz JR, Swanson WJ, Glabe CG, Vacquier. VD;. J Cell Biol 1996;133:809-817.. [2]. 9949214. Identification of a human homologue of the sea urchin receptor. for egg jelly: a polycystic kidney disease-like protein.. Hughes J, Ward CJ, Aspinwall R, Butler R, Harris PC;. Hum Mol Genet 1999;8:543-549. (from Pfam)

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2024-08-14

This short domain is found in many different glycosyl hydrolase enzymes, representing the carbohydrate-binding module family 5/12, including proteins such as chitinase A1, chitinase B, and endoglucanase. The domain has a carbohydrate-binding function and contains six aromatic groups that may be important for binding. These modules have a core structure consisting of a 3-stranded meander beta-sheet [1-5]. [1]. 10788483. Solution structure of the chitin-binding domain of Bacillus. circulans WL-12 chitinase A1.. Ikegami T, Okada T, Hashimoto M, Seino S, Watanabe T, Shirakawa. M;. J Biol Chem. 2000;275:13654-13661.. Paper describing PDB structure 1wvu. [2]. 16516924. Structural studies of a two-domain chitinase from Streptomyces. griseus HUT6037.. Kezuka Y, Ohishi M, Itoh Y, Watanabe J, Mitsutomi M, Watanabe T,. Nonaka T;. J Mol Biol. 2006;358:472-484.. Paper describing PDB structure 2d49. [3]. 16567413. Identification of the substrate interaction region of the. chitin-binding domain of Streptomyces griseus chitinase C.. Akagi K, Watanabe J, Hara M, Kezuka Y, Chikaishi E, Yamaguchi T,. Akutsu H, Nonaka T, Watanabe T, Ikegami T;. J Biochem. 2006;139:483-493.DR CAZY; CBM5;. Paper describing PDB structure 2rts. [4]. 24272751. Solution structure of the chitin-binding domain 1 (ChBD1) of a. hyperthermophilic chitinase from Pyrococcus furiosus.. Mine S, Nakamura T, Sato T, Ikegami T, Uegaki K;. J Biochem. 2014;155:115-122.. [5]. 25479092. Structure-based analysis of domain function of chitin. oligosaccharide deacetylase from Vibrio parahaemolyticus.. Hirano T, Sugiyama K, Sakaki Y, Hakamata W, Park SY, Nishio T;. FEBS Lett.. TRUNCATED at 1650 bytes (from Pfam)

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2024-08-14

This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold [1]. [1]. 7736581. Polycystic kidney disease: the complete structure of the PKD1. gene and its protein.. The International Polycystic Kidney Disease Consortium;. Cell. 1995;81:289-298.. [2]. 9889186. The structure of a PKD domain from polycystin-1: implications. for polycystic kidney disease.. Bycroft M, Bateman A, Clarke J, Hamill SJ, Sandford R, Thomas. RL, Chothia C;. EMBO J 1999;18:297-305. (from Pfam)

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2024-08-14

Date:

2024-08-14