Protein Family Models

The entry represents a domain found in a number of LCP (LytR-Cps2A-Psr) family proteins. LCP family is also known as TagU family. LCP family proteins have been reported to be required for the synthesis of anionic cell wall polymers [1]. [1]. 21964069. A widespread family of bacterial cell wall assembly proteins.. Kawai Y, Marles-Wright J, Cleverley RM, Emmins R, Ishikawa S,. Kuwano M, Heinz N, Bui NK, Hoyland CN, Ogasawara N, Lewis RJ,. Vollmer W, Daniel RA, Errington J;. EMBO J. 2011;30:4931-4941. (from Pfam)

Date:

2024-08-14

This HMM describes a domain of unknown function that is found in the predicted extracellular domain of a number of putative membrane-bound proteins. One of these is proteins psr, described as a penicillin binding protein 5 (PDP-5) synthesis repressor. Another is Bacillus subtilis LytR, described as a transcriptional attenuator of itself and the LytABC operon, where LytC is N-acetylmuramoyl-L-alanine amidase. A third is CpsA, a putative regulatory protein involved in exocellular polysaccharide biosynthesis. Besides the region of strong similarily represented by this HMM, these proteins share the property of having a short putative N-terminal cytoplasmic domain and transmembrane domain forming a signal-anchor.

Date:

2019-09-10