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Links from Protein

Items: 3

1.

Mur ligase family protein

This HMM hits multiple proteins of peptidoglycan (murein) biosynthesis, such as MurC, MurD, MurE, and MurF of Escherichia coli.

GO Terms:
Molecular Function:
ATP binding (GO:0005524)
Biological Process:
biosynthetic process (GO:0009058)
Molecular Function:
acid-amino acid ligase activity (GO:0016881)
Date:
2023-12-12

Family Accession:
NF019850.4
Method:
HMM

2.

bifunctional protein FolC

This HMM represents the FolC family of folate pathway proteins. Most examples are bifunctional, active as both folylpolyglutamate synthetase (EC 6.3.2.17) and dihydrofolate synthetase (EC 6.3.2.12). The two activities are similar - ATP + glutamate + dihydropteroate or tetrahydrofolyl-[Glu](n) = ADP + orthophosphate + dihydrofolate or tetrahydrofolyl-[Glu](n+1). A mutation study of the FolC gene of E. coli suggests that both activities belong to the same active site. Because some examples are monofunctional (and these cannot be separated phylogenetically), the model is treated as subfamily, not equivalog.

Gene:
folC
GO Terms:
Molecular Function:
tetrahydrofolylpolyglutamate synthase activity (GO:0004326)
Cellular Component:
cytoplasm (GO:0005737)
Biological Process:
folic acid-containing compound metabolic process (GO:0006760)
Molecular Function:
dihydrofolate synthase activity (GO:0008841)
Biological Process:
tetrahydrofolate biosynthetic process (GO:0046654)
Date:
2021-04-27

Family Accession:
TIGR01499.1
Method:
HMM

3.

bifunctional tetrahydrofolate synthase/dihydrofolate synthase

Gene:
folC
GO Terms:
Molecular Function:
tetrahydrofolylpolyglutamate synthase activity (GO:0004326)
Molecular Function:
ATP binding (GO:0005524)
Biological Process:
folic acid-containing compound biosynthetic process (GO:0009396)
Molecular Function:
ligase activity (GO:0016874)
Date:
2021-07-23

Family Accession:
NF008101.0
Method:
HMM

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