Protein Family Models

This family contains a number of bacterial Na+/H+ antiporter 1 proteins. These are integral membrane proteins that catalyse the exchange of H+ for Na+ in a manner that is highly dependent on the pH [1]. [1]. 1657980. Expression of a sodium proton antiporter (NhaA) in Escherichia. coli is induced by Na+ and Li+ ions.. Karpel R, Alon T, Glaser G, Schuldiner S, Padan E;. J Biol Chem 1991;266:21753-21759. (from Pfam)

Date:

2024-08-14

These proteins are members of the NhaA Na+:H+ Antiporter (NhaA) Family (TC. 2.A.33). The Escherichia coli NhaA protein probably functions in the regulation of the internal pH when the external pH is alkaline. It also uses the H+ gradient to expel Na+ from the cell. Its activity is highly pH dependent. Only the E. coli protein is functionally and structurally well characterized.

Gene:

nhaA

Date:

2024-06-04

Exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH

Gene:

nhaA

Date:

2020-10-26

Exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH

Gene:

nhaA

Date:

2020-10-26