Protein Family Models

This family contains diverse flavoprotein enzymes. This family includes epidermin biosynthesis protein, EpiD Swiss:P30197, which has been shown to be a flavoprotein that binds FMN [1]. This enzyme catalyses the removal of two reducing equivalents from the cysteine residue of the C-terminal meso-lanthionine of epidermin to form a --C==C-- double bond. This family also includes the B chain of dipicolinate synthase a small polar molecule that accumulates to high concentrations in bacterial endospores, and is thought to play a role in spore heat resistance, or the maintenance of heat resistance [2]. dipicolinate synthase catalyses the formation of dipicolinic acid from dihydroxydipicolinic acid. This family also includes phenyl-acrylic acid decarboxylase Swiss:P33751 (EC:4.1.1.-) [3]. [1]. 1644762. Purification and characterization of EpiD, a flavoprotein. involved in the biosynthesis of the lantibiotic epidermin.. Kupke T, Stevanovic S, Sahl HG, Gotz F;. J Bacteriol 1992;174:5354-5361.. [2]. 8345520. Cloning, DNA sequence, functional analysis and transcriptional. regulation of the genes encoding dipicolinic acid synthetase. required for sporulation in Bacillus subtilis.. Daniel RA, Errington J;. J Mol Biol 1993;232:468-483.. [3]. 8181743. PAD1 encodes phenylacrylic acid decarboxylase which confers. resistance to cinnamic acid in Saccharomyces cerevisiae.. Clausen M, Lamb CJ, Megnet R, Doerner PW;. Gene 1994;142:107-112. (from Pfam)

Date:

2024-08-14

UbiX family flavin prenyltransferase such as UbiX, which produces a flavin-derived cofactor required for the decarboxylase activity of UbiD

Date:

2017-12-12

UbiX partners with UbiD for decarboxylation of the 3-octaprenyl-4-hydroxybenzoate precursor during ubiquinone biosynthesis, but the role of UbiX is as a flavin prenyltransferase that provides a cofactor UbiD requires.

Date:

2024-05-07