Protein Family Models for Protein (Select 2206100059) - Protein Family Models

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Items: 5

Select item 4119511.

FtsW/RodA/SpoVE family cell cycle protein

This entry includes the following members; FtsW, RodA, SpoVE (from Pfam)

GO Terms:

Cellular Component:: membrane (GO:0016020)

Biological Process:: cell division (GO:0051301)

Date:: 2024-08-14

Family Accession:: NF013279.5
Method:: HMM

Select item 3889232.

new record, indexing in progress

Family Accession:

Select item 3481493.

new record, indexing in progress

Family Accession:

Select item 506434.

putative lipid II flippase FtsW

This family consists of FtsW, an integral membrane protein with ten transmembrane segments [1]. In general, it is one of two paralogs involved in peptidoglycan biosynthesis, the other being RodA, and is essential for cell division. All members of the seed alignment for this model are encoded in operons for the biosynthesis of UDP-N-acetylmuramoyl-pentapeptide, a precursor of murein (peptidoglycan). The FtsW designation is not used in endospore-forming bacterial (e.g. Bacillus subtilis), where the member of this family is designated SpoVE and three or more RodA/FtsW/SpoVE family paralogs are present. SpoVE acts in spore cortex formation and is dispensible for growth. Biological rolls for FtsW in cell division include recruitment of penicillin-binding protein 3 to the division site.