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Bifunctional transglycosylase second domain
UB2H is the second domain of the transglycosylases, or penicillin-binding proteins PBP1bs)), the multi-domain membrane proteins essential for cell wall synthesis that are targeted by penicillin antibiotics. The exact function of the UB2H domain is uncertain, but it may act as the binding component of PBP1b with different binding partners, or it may participate in the regulation between DNA repair and/or synthesis and cell wall formation during the bacterial cell cycle [1]. [1]. 19458048. Crystal structure of the membrane-bound bifunctional. transglycosylase PBP1b from Escherichia coli.. Sung MT, Lai YT, Huang CY, Chou LY, Shih HW, Cheng WC, Wong CH,. Ma C;. Proc Natl Acad Sci U S A. 2009;106:8824-8829. (from Pfam)
transglycosylase domain-containing protein
The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively [1]. The transglycosylase domain catalyses the polymerisation of murein glycan chains ([4]). [1]. 9244263. Topographical and functional investigation of Escherichia coli. penicillin-binding protein 1b by alanine stretch scanning. mutagenesis.. F. Lefevre, M. H. Remy & J. M. Masson;. J Bacteriol 1997;179:4761-4767.. [2]. 9614972. X-ray studies of enzymes that interact with penicillins.. Kelly JA, Kuzin AP, Charlier P, Fonze E;. Cell Mol Life Sci 1998;54:353-358.. [3]. 8830253. Monofunctional biosynthetic peptidoglycan transglycosylases.. Spratt BG, Zhou J, Taylor M, Merrick MJ;. Mol Microbiol 1996;19:639-640.. [4]. 12867450. The glycosyltransferase domain of penicillin-binding protein 2a. from Streptococcus pneumoniae catalyzes the polymerization of. murein glycan chains.. Di Guilmi AM, Dessen A, Dideberg O, Vernet T;. J Bacteriol 2003;185:4418-4423. (from Pfam)
penicillin-binding transpeptidase domain-containing protein
The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family. [1]. 8605631. X-ray structure of Streptococcus pneumoniae PBP2x, a primary. penicillin target enzyme.. Pares S, Mouz N, Petillot Y, Hakenbeck R, Dideberg O. Nat Struct Biol 1996;3:284-289. (from Pfam)
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