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MFS transporter
Fungal trichothecene efflux pump (TRI12)
This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes [1]. [1]. 10485289. TRI12, a trichothecene efflux pump from Fusarium. sporotrichioides: gene isolation and expression in yeast.. Alexander NJ, McCormick SP, Hohn TM;. Mol Gen Genet 1999;261:977-984. (from Pfam)
DHA2 family efflux MFS transporter permease subunit
This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli.
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