Protein Family Models

Members of this family are integral membrane proteins. The decarboxylation reactions they catalyse are coupled to the vectorial transport of Na+ across the cytoplasmic membrane, thereby creating a sodium ion motive force that is used for ATP synthesis [2]. [1]. 2549031. The sodium ion translocating oxaloacetate decarboxylase of. Klebsiella pneumoniae. Sequence of the integral membrane-bound. subunits beta and gamma.. Laussermair E, Schwarz E, Oesterhelt D, Reinke H, Beyreuther K,. Dimroth P;. J Biol Chem 1989;264:14710-14715.. [2]. 9428714. Methylmalonyl-CoA decarboxylase from Propionigenium. modestum--cloning and sequencing of the structural genes and. purification of the enzyme complex.. Bott M, Pfister K, Burda P, Kalbermatter O, Woehlke G, Dimroth. P;. Eur J Biochem 1997;250:590-599. (from Pfam)

Date:

2024-08-14

This model describes the beta subunits of sodium pump decarboxylases that include oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, and glutaconyl-CoA decarboxylase. Beta and gammma-subunits are integral membrane proteins, while alpha is membrane bound. Catalytically, the energy released by the decarboxylation reaction is coupled to the extrusion of Na+ ions across the membrane.

Date:

2024-05-30