Protein Family Models

Date:

2024-08-14

This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor. [1]. 8831789. Crystal structure of the pyridoxal-5'-phosphate dependent. cystathionine beta-lyase from Escherichia coli at 1.83 A.. Clausen T, Huber R, Laber B, Pohlenz HD, Messerschmidt A;. J Mol Biol 1996;262:202-224.. [2]. 9843488. Crystal structure of Escherichia coli cystathionine. gamma-synthase at 1.5 A resolution.. Clausen T, Huber R, Prade L, Wahl MC, Messerschmidt A;. EMBO J 1998;17:6827-6838. (from Pfam)

Date:

2024-08-14

The members of this family are probably all pyridoxal-phosphate-dependent aminotransferase enzymes with a variety of molecular functions. The family includes StsA Swiss:P72454, StsC Swiss:P77952 and StsS [1]. The aminotransferase activity was demonstrated for purified StsC protein as the L-glutamine:scyllo-inosose aminotransferase EC:2.6.1.50, which catalyses the first amino transfer in the biosynthesis of the streptidine subunit of streptomycin [1]. [1]. 9238101. Identification of stsC, the gene encoding the. L-glutamine:scyllo-inosose aminotransferase from. streptomycin-producing Streptomycetes.. Ahlert J, Distler J, Mansouri K, Piepersberg W;. Arch Microbiol 1997;168:102-113. (from Pfam)

Date:

2024-08-14

trans-sulfuration enzyme family protein belongs to the PLP-dependent aspartate aminotransferase superfamily, such as cystathionine gamma-synthase and cystathionine beta-lyase

Date:

2024-07-08