Protein Family Models

UreD is a urease accessory protein. Urease Pfam:PF00449 hydrolyses urea into ammonia and carbamic acid [2]. UreD is involved in activation of the urease enzyme via the UreD-UreF-UreG-urease complex [1] and is required for urease nickel metallocenter assembly [3]. See also UreF Pfam:PF01730, UreG Pfam:PF01495. [1]. 9209019. Characterization of UreG, identification of a UreD-UreF-UreG. complex, and evidence suggesting that a nucleotide-binding site. in UreG is required for in vivo metallocenter assembly of. Klebsiella aerogenes urease.. Moncrief MB, Hausinger RP;. J Bacteriol 1997;179:4081-4086.. [2]. 8550495. Organization of Ureaplasma urealyticum urease gene cluster and. expression in a suppressor strain of Escherichia coli.. Neyrolles O, Ferris S, Behbahani N, Montagnier L, Blanchard A;. J Bacteriol 1996;178:647-655.. [3]. 7909161. In vitro activation of urease apoprotein and role of UreD as a. chaperone required for nickel metallocenter assembly.. Park IS, Carr MB, Hausinger RP;. Proc Natl Acad Sci U S A 1994;91:3233-3237. (from Pfam)

Date:

2024-08-14

urease accessory protein UreD/UreH forms a complex together with UreF and UreG that acts as a GTP-hydrolysis-dependent molecular chaperone which is required for maturation of urease via the functional incorporation of the urease nickel metallocenter

Date:

2016-09-24