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LicD family protein
The LICD family of proteins show high sequence similarity and are involved in phosphorylcholine metabolism. There is evidence to show that LicD2 mutants have a reduced ability to take up choline, have decreased ability to adhere to host cells and are less virulent [1]. These proteins are part of the nucleotidyltransferase superfamily [2]. [1]. 10200966. Pneumococcal licD2 gene is involved in phosphorylcholine. metabolism.. Zhang JR, Idanpaan-Heikkila I, Fischer W, Tuomanen EI;. Mol Microbiol 1999;31:1477-1488.. [2]. 19833706. Comprehensive classification of nucleotidyltransferase fold. proteins: identification of novel families and their. representatives in human.. Kuchta K, Knizewski L, Wyrwicz LS, Rychlewski L, Ginalski K;. Nucleic Acids Res. 2009; [Epub ahead of print] (from Pfam)
LicD family protein similar to Saccharomyces cerevisiae protein MNN4, which is required to mediate mannosylphosphate transfer in both the core and outer chain portions of N-linked oligosaccharides
phosphorylcholine transferase LicD
phosphorylcholine transferase LicD transfers phosphorylcholine (ChoP) from choline diphosphonucleoside to the lipopolysaccharide (LPS)
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