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DnaK suppressor protein DksA, N-terminal domain
TraR/DksA C4-type zinc finger protein
RNA polymerase-binding protein DksA
DksA (DnaK suppressor A) is a small, pleiotropic protein that binds RNA polymerase. It helps the signaling molecule ppGpp mediate the stringent response, causing changes in transcription initiation rates such as a dramatic decrease for rRNA. While forms of DksA are found broadly in bacteria, this HMM largely describes DksA as found in Proteobacteria.
RNA polymerase-binding protein DksA is required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
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