Protein Family Models

This domain is found in a wide variety of proteins. These protein include potassium channels Swiss:P31069, phosphoesterases Swiss:Q59027, and various other transporters. This domain binds to NAD. Domain called KTN in figure 2.. [1]. 9478130. A novel family of predicted phosphoesterases includes Drosophila. prune protein and bacterial RecJ exonuclease.. Aravind L, Koonin EV;. Trends Biochem Sci 1998;23:17-19.. [2]. 8412700. NAD+ binding to the Escherichia coli K(+)-uptake protein TrkA. and sequence similarity between TrkA and domains of a family of. dehydrogenases suggest a role for NAD+ in bacterial transport.. Schlosser A, Hamann A, Bossemeyer D, Schneider E, Bakker EP;. Mol Microbiol 1993;9:533-543.. Called TRKA-N domain. See alignment in figure 8a.. [3]. 11292341. Regulatory potential, phyletic distribution and evolution of. ancient, intracellular small-molecule-binding domains.. Anantharaman V, Koonin EV, Aravind L;. J Mol Biol 2001;307:1271-1292. (from Pfam)

Date:

2024-08-14

potassium channel family protein spans the cell membrane to form a conduction pathway or pore, through which selective ions such as potassium, sodium, and calcium translocate across cell membranes, similar to Trk system potassium uptake protein TrkA

Date:

2024-07-12