Protein Family Models for Protein (Select 1592171401) - Protein Family Models

Select item 4304221.

Homocitrate synthase post-HMGL domain-like

Date:: 2024-08-14

Family Accession:: NF046876.1
Method:: HMM

Select item 4184922.

alpha-isopropylmalate synthase regulatory domain-containing protein

This is the C-terminal regulatory (R) domain of alpha-isopropylmalate synthase, which catalyses the first committed step in the leucine biosynthetic pathway [1]. This domain, is an internally duplicated structure with a novel fold [1]. It comprises two similar units that are arranged such that the two -helices pack together in the centre, crossing at an angle of 34 degrees, sandwiched between the two three-stranded, antiparallel beta-sheets. The overall domain is thus constructed as a beta-alpha-beta three-layer sandwich [1]. [1]. 15159544. Crystal structure of LeuA from Mycobacterium tuberculosis, a key. enzyme in leucine biosynthesis.. Koon N, Squire CJ, Baker EN;. Proc Natl Acad Sci U S A 2004;101:8295-8300. (from Pfam)

GO Terms:

Molecular Function:: 2-isopropylmalate synthase activity (GO:0003852)

Biological Process:: L-leucine biosynthetic process (GO:0009098)

Date:: 2024-08-14

Family Accession:: NF020091.5
Method:: HMM

Select item 4116603.

HMGL-like

This family contains a diverse set of enzymes. These include various aldolases and a region of pyruvate carboxylase. (from Pfam)

GO Terms:

Molecular Function:: catalytic activity (GO:0003824)

Date:: 2024-08-14

Family Accession:: NF012885.5
Method:: HMM

Select item 3955654.

new record, indexing in progress

Family Accession:

Select item 3899645.

new record, indexing in progress

Family Accession:

Select item 3579536.

new record, indexing in progress

Family Accession:

Select item 3468697.

new record, indexing in progress

Family Accession:

Select item 2268908.

2-isopropylmalate synthase

2-isopropylmalate synthase converts acetyl-CoA and alpha-ketoisovalerate into alpha-isopropylmalate in the committed step of leucine biosynthesis

Date:: 2023-03-02

Family Accession:: 11479332
Method:: Sparcle

Select item 1770389.

2-isopropylmalate synthase

GO Terms:

Molecular Function:: 2-isopropylmalate synthase activity (GO:0003852)

Biological Process:: L-leucine biosynthetic process (GO:0009098)

Biological Process:: carboxylic acid metabolic process (GO:0019752)

Date:: 2021-08-23

Family Accession:: NF002086.0
Method:: HMM

Select item 17623910.

2-isopropylmalate synthase

Date:: 2020-10-26

Family Accession:: NF002085.0
Method:: HMM

Select item 2453811.

2-isopropylmalate synthase

This is the first enzyme of leucine biosynthesis. A larger family of homologous proteins includes homocitrate synthase, distinct lineages of 2-isopropylmalate synthase, several distinct, uncharacterized, orthologous sets in the Archaea, and other related enzymes. This model describes a family of 2-isopropylmalate synthases found primarily in Bacteria. The homologous families in the Archaea may represent isozymes and/or related enzymes.

Gene:: leuA

GO Terms:

Molecular Function:: 2-isopropylmalate synthase activity (GO:0003852)

Biological Process:: L-leucine biosynthetic process (GO:0009098)

Date:: 2021-04-27

Family Accession:: TIGR00973.1
Method:: HMM

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