Protein Family Models

Date:

2024-08-14

This domain lies at the C-terminus of the delta subunit of the DNA polymerase III clamp loader gamma complex. Within the complex the several C-terminal domains, of gamma, delta and delta' form a helical scaffold, on which the rest of he subunits are hung. The gamma complex, an AAA+ ATPase, is the bacterial homologue of the eukaryotic replication factor C that loads the sliding clamp (beta, homologous to PCNA) onto DNA. [1]. 11525729. Crystal structure of the processivity clamp loader gamma (gamma). complex of E. coli DNA polymerase III.. Jeruzalmi D, O'Donnell M, Kuriyan J;. Cell. 2001;106:429-441. (from Pfam)

Date:

2024-08-14

DNA polymerase III, delta subunit (EC 2.7.7.7) is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalysed reaction [1]. The delta subunit is also known as HolA. [1]. 11432857. The delta and delta ' subunits of the DNA polymerase III. holoenzyme are essential for initiation complex formation and. processive elongation.. Song MS, Pham PT, Olson M, Carter JR, Franden MA, Schaaper RM,. McHenry CS;. J Biol Chem 2001;276:35165-35175. (from Pfam)

Date:

2024-08-14

DNA polymerase III delta (holA) and delta-prime (holB) subunits are distinct proteins encoded by separate genes. The delta, delta-prime, gamma, chi and psi subunits form the gamma complex subassembly of DNA polymerase III holoenzyme, which couples ATP to assemble the ring-shaped beta subunit around DNA forming a DNA sliding clamp.

Gene:

holA

Date:

2024-05-14

DNA polymerase III subunit delta interacts with the delta' and gamma subunits and is part of the clamp-loading complex, which assembles the beta processivity factor onto the primer template, plays a central role in the organization and communication at the replication fork and present in initiation complex which is required for processive elongation.

Date:

2022-08-05