Protein Family Models

Flagellins polymerise to form bacterial flagella. There is some similarity between this family and Pfam:PF00669, particularly the motif NRFXSXIXXL. It has been suggested that these two regions associate [2] and this is shown to be correct as structurally this family forms an extended helix that interacts with Pfam:PF00700. [1]. 7648320. Spinning tails.. DeRosier DJ;. Curr Opin Struct Biol 1995;5:187-193.. [2]. 2190210. Flagellin as an object for supramolecular engineering.. Fedorov OV, Efimov AV;. Protein Eng 1990;3:411-413. (from Pfam)

Date:

2024-04-03

Flagellins polymerise to form bacterial flagella. This family includes flagellins and hook associated protein 3. Structurally this family forms an extended helix that interacts with Pfam:PF00700. [1]. 7648320. Spinning tails.. DeRosier DJ;. Curr Opin Struct Biol 1995;5:187-193. (from Pfam)

Date:

2024-04-03

Flagellinolysin is a variant form of bacterial flagellin in with the normally hypervariable central region contains an M9 (MEROPS classification) family metalloprotease domain, with its signature HExxH motif. The founding member of the family, from the pathogen Clostridium haemolyticum, shows EDTA-sensitive metalloprotease activity. The large count of flagellin subunits in a complete flagellum means the capacity of flagellinolysin to perform as a protease may have implications for host-pathogen relationships.

Date:

2021-06-17