Protein Family Models for Protein (Select 1199603883) - Protein Family Models

Select item 4124361.

transcription termination/antitermination NusG family protein

GO Terms:

Biological Process:: DNA-templated transcription elongation (GO:0006354)

Biological Process:: regulation of DNA-templated transcription (GO:0006355)

Biological Process:: transcription elongation-coupled chromatin remodeling (GO:0140673)

Date:: 2024-08-14

Family Accession:: NF014417.5
Method:: HMM

Select item 4118962.

KOW motif-containing protein

This family has been extended to coincide with ref [1]. The KOW (Kyprides, Ouzounis, Woese) motif is found in a variety of ribosomal proteins and NusG. [1]. 8987397. KOW: a novel motif linking a bacterial transcription factor with. ribosomal proteins.. Kyrpides NC, Woese CR, Ouzounis CA;. Trends Biochem Sci 1996;21:425-426. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF012680.5
Method:: HMM

Select item 3896423.

new record, indexing in progress

Family Accession:

Select item 3884004.

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Family Accession:

Select item 3484805.

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Family Accession:

Select item 3465496.

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Family Accession:

Select item 3174147.

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Select item 3155938.

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Select item 1434999.

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Family Accession:

Select item 14339710.

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Family Accession:

Select item 9147611.

transcription termination/antitermination protein NusG

transcription termination/antitermination protein NusG (N-Utilization Substance G) is involved in transcription elongation and termination in bacteria

Date:: 2022-09-13

Family Accession:: 11415705
Method:: Sparcle

Select item 2483212.

transcription termination/antitermination protein NusG

NusG proteins are transcription factors which are aparrently universal in prokaryotes (archaea and eukaryotes have homologs that may have related functions). The essential components of these factors include an N-terminal RNP-like (ribonucleoprotein) domain and a C-terminal KOW motif (PF00467) believed to be a nucleic acid binding domain [3]. In E. coli, NusA has been shown to interact with RNA polymerase and termination factor Rho. This model covers a wide variety of bacterial species but excludes mycoplasmas which are covered by a separate model (TIGR01956). The function of all of these NusG proteins is likely to be the same at the level of interaction with RNA and other protein factors to affect termination; however different species may utilize NusG towards different processes and in combination with different suites of affector proteins. In E. coli, NusG promotes rho-dependent termination. It is an essential gene. In Streptomyces virginiae and related species, an additional N-terminal sequence is also present and is suggested to play a role in butyrolactone-mediated autoregulation. In Thermotoga maritima, NusG has a long insert, fails to substitute for E. coli NusG (with or without the long insert), is a large 0.7 % of total cellular protein, and has a general, sequence non-specific DNA and RNA binding activity that blocks ethidium staining, yet permits transcription. Archaeal proteins once termed NusG share the KOW domain but are actually a ribosomal protein corresponding to L24p in bacterial and L26e in eukaryotes (TIGR00405).

Gene:: nusG

GO Terms:

Biological Process:: regulation of DNA-templated transcription elongation (GO:0032784)

Date:: 2024-06-26

Family Accession:: TIGR00922.1
Method:: HMM

Select item 372213.

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Select item 341514.

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