Protein Family Models

This domain has a ferredoxin-like fold. [1]. 9141139. Crystallization and preliminary X-ray analysis of the. flavoenzyme vanillyl-alcohol oxidase from Penicillium. simplicissimum.. Mattevi A, Fraaije MW, Coda A, van Berkel WJ;. Proteins 1997;27:601-603. (from Pfam)

Date:

2024-08-14

This family consists of various enzymes that use FAD as a co-factor, most of the enzymes are similar to oxygen oxidoreductase. One of the enzymes Vanillyl-alcohol oxidase (VAO) has a solved structure, the alignment includes the FAD binding site, called the PP-loop, between residues 99-110 [1]. The FAD molecule is covalently bound in the known structure, however the residue that links to the FAD is not in the alignment. VAO catalyses the oxidation of a wide variety of substrates, ranging form aromatic amines to 4-alkylphenols. Other members of this family include D-lactate dehydrogenase, this enzyme catalyses the conversion of D-lactate to pyruvate using FAD as a co-factor; mitomycin radical oxidase, this enzyme oxidises the reduced form of mitomycins and is involved in mitomycin resistance. This family includes MurB an UDP-N-acetylenolpyruvoylglucosamine reductase enzyme EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan [2]. [1]. 9261083. Crystal structures and inhibitor binding in the octameric. flavoenzyme vanillyl-alcohol oxidase: the shape of the. active-site cavity controls substrate specificity.. Mattevi A, Fraaije MW, Mozzarelli A, Olivi L, Coda A, van Berkel. WJ;. Structure 1997;5:907-920.. [2]. 8805513. The structure of the substrate-free form of MurB, an essential. enzyme for the synthesis of bacterial cell walls.. Benson TE, Walsh CT, Hogle JM;. Structure 1996;4:47-54. (from Pfam)

Date:

2024-08-14

FAD-binding oxidoreductase catalyzes the oxidation or reduction of a specific substrate using flavin adenine dinucleotide (FAD) as a cofactor

Date:

2024-04-16