Protein Family Models for Protein (Select 1121577466) - Protein Family Models

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Items: 4

Select item 4113301.

tyrosine-type recombinase/integrase

Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. The catalytic site residues in CRE recombinase (Swiss:P06956) are Arg-173, His-289, Arg-292 and Tyr-324. [1]. 9082984. Flexibility in DNA recombination: structure of the lambda. integrase catalytic core.. Kwon HJ, Tirumalai R, Landy A, Ellenberger T;. Science 1997;276:126-131.. [2]. 9288963. Structure of Cre recombinase complexed with DNA in a. site-specific recombination synapse.. Guo F, Gopaul DN, van Duyne GD;. Nature 1997;389:40-46. (from Pfam)

GO Terms:

Molecular Function:: DNA binding (GO:0003677)

Biological Process:: DNA recombination (GO:0006310)

Biological Process:: DNA integration (GO:0015074)

Date:: 2024-08-14

Family Accession:: NF012798.5
Method:: HMM

Select item 3891502.

new record, indexing in progress

Family Accession:

Select item 3467593.

new record, indexing in progress

Family Accession:

Select item 2366994.

site-specific integrase

tyrosine based site-specific recombinase (integrase) is involved in cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct