Protein Family Models for Protein (Select 1092786381) - Protein Family Models

Select item 4019661.

This domain is most frequently found at the N-terminus of the ThiC family of proteins, Pfam:PF01964. The function is not known. (from Pfam)

Date:: 2023-12-12

Family Accession:: NF025048.4
Method:: HMM

Select item 3912742.

phosphomethylpyrimidine synthase ThiC

ThiC is found within the thiamine biosynthesis operon. ThiC is involved in pyrimidine biosynthesis [1]. ThiC participates in the formation of 4-Amino-5-hydroxymethyl-2-methylpyrimidine from AIR, an intermediate in the de novo pyrimidine biosynthesis. Thic is a member of the radical SAM superfamily [3]. [1]. 8432721. Structural genes for thiamine biosynthetic enzymes (thiCEFGH) in. Escherichia coli K-12.. Vander Horn PB, Backstrom AD, Stewart V, Begley TP;. J Bacteriol 1993;175:982-992.. [2]. 10382260. Thiamin biosynthesis in prokaryotes.. Begley TP, Downs DM, Ealick SE, McLafferty FW, Van Loon AP,. Taylor S, Campobasso N, Chiu HJ, Kinsland C, Reddick JJ, Xi J;. Arch Microbiol 1999;171:293-300.. [3]. 18953358. Reconstitution of ThiC in thiamine pyrimidine biosynthesis. expands the radical SAM superfamily.. Chatterjee A, Li Y, Zhang Y, Grove TL, Lee M, Krebs C, Booker. SJ, Begley TP, Ealick SE;. Nat Chem Biol. 2008;4:758-765. (from Pfam)

GO Terms:

Biological Process:: thiamine biosynthetic process (GO:0009228)

Molecular Function:: iron-sulfur cluster binding (GO:0051536)

Date:: 2024-04-03

Family Accession:: NF014067.4
Method:: HMM

Select item 3581813.

new record, indexing in progress

Family Accession:

Select item 3473084.

new record, indexing in progress

Family Accession:

Select item 3327655.

new record, indexing in progress

Family Accession:

Select item 3176686.

new record, indexing in progress

Family Accession:

Select item 1929797.

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Family Accession:

Select item 1923588.

new record, indexing in progress

Family Accession:

Select item 1864989.

phosphomethylpyrimidine synthase ThiC

Catalyzes the formation of 4-amino-2-methyl-5-phosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole and S-adenosyl-L-methionine in thiamine biosynthesis

Gene:: thiC

GO Terms:

Biological Process:: thiamine biosynthetic process (GO:0009228)

Molecular Function:: iron-sulfur cluster binding (GO:0051536)

Date:: 2021-09-01

Family Accession:: NF009895.0
Method:: HMM

Select item 16859510.

phosphomethylpyrimidine synthase ThiC

Catalyzes the formation of 4-amino-2-methyl-5-phosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole and S-adenosyl-L-methionine in thiamine biosynthesis

Gene:: thiC

GO Terms:

Biological Process:: thiamine biosynthetic process (GO:0009228)

Molecular Function:: iron-sulfur cluster binding (GO:0051536)

Date:: 2021-07-22

Family Accession:: NF006763.1
Method:: HMM

Select item 15198311.

new record, indexing in progress

Family Accession:

Select item 15187912.

new record, indexing in progress

Family Accession:

Select item 12902413.

phosphomethylpyrimidine synthase ThiC

phosphomethylpyrimidine synthase ThiC catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction

GO Terms:

Biological Process:: thiamine biosynthetic process (GO:0009228)

Molecular Function:: 4 iron, 4 sulfur cluster binding (GO:0051539)

Molecular Function:: S-adenosyl-L-methionine binding (GO:1904047)

Date:: 2023-03-16

Family Accession:: 11483760
Method:: Sparcle

Select item 1612614.

phosphomethylpyrimidine synthase

The thiC ortholog is designated thiA in Bacillus subtilis.

Gene:: thiC

GO Terms:

Molecular Function:: catalytic activity (GO:0003824)

Biological Process:: thiamine biosynthetic process (GO:0009228)

Date:: 2021-04-27

Family Accession:: TIGR00190.1
Method:: HMM

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