Protein Family Models for Protein (Select 1055568352) - Protein Family Models

Select item 4258281.

ankyrin repeat domain-containing protein

GO Terms:

Molecular Function:: protein binding (GO:0005515)

Date:: 2024-08-14

Family Accession:: NF025021.5
Method:: HMM

Select item 4226292.

ankyrin repeat domain-containing protein

GO Terms:

Molecular Function:: protein binding (GO:0005515)

Date:: 2024-08-14

Family Accession:: NF024206.5
Method:: HMM

Select item 4224273.

ankyrin repeat protein

GO Terms:

Molecular Function:: protein binding (GO:0005515)

Date:: 2024-08-14

Family Accession:: NF024993.5
Method:: HMM

Select item 4156474.

suppressor of fused domain protein

SUFU, encoding the human orthologue of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus [1]. SUFU has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway [2]. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems [3]. [1]. 12150819. Medulloblastoma: A problem of developmental biology.. Rubin JB, Rowitch DH;. Cancer Cell 2002;2:7-8.. [2]. 12068298. Mutations in SUFU predispose to medulloblastoma.. Taylor MD, Liu L, Raffel C, Hui CC, Mainprize TG, Zhang X,. Agatep R, Chiappa S, Gao L, Lowrance A, Hao A, Goldstein AM,. Stavrou T, Scherer SW, Dura WT, Wainwright B, Squire JA, Rutka. JT, Hogg D;. Nat Genet 2002;31:306-310.. [3]. 21306995. A novel immunity system for bacterial nucleic acid degrading. toxins and its recruitment in various eukaryotic and DNA viral. systems.. Zhang D, Iyer LM, Aravind L;. Nucleic Acids Res. 2011;39:4532-4552. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF016932.5
Method:: HMM

Select item 4109815.

ankyrin repeat protein

Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity [2][3]. [1]. 2141669. Hereditary spherocytosis associated with deletion of human. erythrocyte ankyrin gene on chromosome 8.. Lux SE, John KM, Bennett V;. Nature 1990;345:736-739.. [2]. 12456646. Crystal structure of a 12 ANK repeat stack from human ankyrinR.. Michaely P, Tomchick DR, Machius M, Anderson RG;. EMBO J. 2002;21:6387-6396.. [3]. 14731966. The ANK repeat: a ubiquitous motif involved in macromolecular. recognition.. Michaely P, Bennett V;. Trends Cell Biol. 1992;2:127-129. (from Pfam)

GO Terms:

Molecular Function:: protein binding (GO:0005515)

Date:: 2024-08-14

Family Accession:: NF012253.5
Method:: HMM

Select item 4019636.