Protein Family Models for Gene (Select 8382867) - Protein Family Models

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Items: 7

Select item 3921711.

new record, indexing in progress

Family Accession:

Select item 3900892.

new record, indexing in progress

Family Accession:

Select item 3483153.

new record, indexing in progress

Family Accession:

Select item 3470144.

new record, indexing in progress

Family Accession:

Select item 2443665.

new record, indexing in progress

Family Accession:

Select item 246206.

bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

Gene:: purH

GO Terms:

Molecular Function:: catalytic activity (GO:0003824)

Molecular Function:: IMP cyclohydrolase activity (GO:0003937)

Molecular Function:: phosphoribosylaminoimidazolecarboxamide formyltransferase activity (GO:0004643)

Biological Process:: purine nucleotide biosynthetic process (GO:0006164)

Biological Process:: 'de novo' IMP biosynthetic process (GO:0006189)

Date:: 2021-07-21

Family Accession:: NF002049.0
Method:: HMM

Select item 216577.

phosphoribosylglycinamide formyltransferase

This HMM describes phosphoribosylglycinamide formyltransferase (GAR transformylase), one of several proteins in formyl_transf (Pfam family PF00551). This enzyme uses formyl tetrahydrofolate as a formyl group donor to produce 5'-phosphoribosyl-N-formylglycinamide. PurT, a different GAR transformylase, uses ATP and formate rather than formyl tetrahydrofolate. Experimental proof includes complementation of E. coli purN mutants by orthologs from vertebrates (where it is a domain of a multifunctional protein), Bacillus subtilis, and Arabidopsis. No archaeal example was detected. In phylogenetic analyses, the member from Saccharomyces cerevisiae shows a long branch length but membership in the family, while the formyltetrahydrofolate deformylases form a closely related outgroup.