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Items: 11

1.
new record, indexing in progress
Family Accession:
2.
new record, indexing in progress
Family Accession:
3.
new record, indexing in progress
Family Accession:
4.

KEOPS complex N(6)-L-threonylcarbamoyladenine synthase Kae1

This family represents the archaeal protein Kae1. Its partner Bud32 is fused with it in about half of the known archaeal genomes. The pair, which appears universal in the archaea, corresponds to EKC/KEOPS complex in eukaryotes. A recent characterization of the member from Pyrococcus abyssi, as an iron-binding, atypical DNA-binding protein with an apurinic lyase activity, challenges the common annotation of close homologs as O-sialoglycoprotein endopeptidase. The latter annotation is based on a characterized protein from the bacterium Pasteurella haemolytica.

Gene:
kae1
GO Terms:
Molecular Function:
N(6)-L-threonylcarbamoyladenine synthase activity (GO:0061711)
Date:
2022-07-16
Family Accession:
TIGR03722.2
Method:
HMM
5.

KEOPS complex kinase/ATPase Bud32

Members of this protein family are the Bud32 protein associated with Kae1 (kinase-associated endopeptidase 1) in the Archaea. In many Archaeal genomes, Kae1 and Bud32 are fused. The complex is homologous to the Kae1 and Bud32 subunits of the eukaryotic KEOPS complex, an apparently ancient protein kinase-containing molecular machine.

GO Terms:
Molecular Function:
protein serine/threonine kinase activity (GO:0004674)
Date:
2024-05-30
Family Accession:
TIGR03724.2
Method:
HMM
6.
new record, indexing in progress
Family Accession:
7.
new record, indexing in progress
Family Accession:
8.

bifunctional N(6)-L-threonylcarbamoyladenine synthase/serine/threonine protein kinase

bifunctional N(6)-L-threonylcarbamoyladenine synthase/serine/threonine protein kinase is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine, and also displays kinase activity that regulates Kae1 function

Date:
2019-05-31
Family Accession:
11484404
Method:
Sparcle
9.

tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD

This subfamily includes the well-studied secreted O-sialoglycoprotein endopeptidase (glycoprotease, EC 3.4.24.57) of Pasteurella haemolytica, a pathogen. A member from Riemerella anatipestifer, associated with cohemolysin activity, likewise is exported without benefit of a classical signal peptide and shows glycoprotease activity on the test substrate glycophorin. However, archaeal members of this subfamily show unrelated activities as demonstrated in Pyrococcus abyssi: DNA binding, iron binding, apurinic endonuclease activity, genomic association with a kinase domain, and no glycoprotease activity. This family thus pulls together a set of proteins as a homology group that appears to be near-universal in life, yet heterogeneous in assayed function between bacteria and archaea.

Gene:
tsaD
Date:
2019-09-10
Family Accession:
TIGR00329.1
Method:
HMM
10.

bifunctional N(6)-L-threonylcarbamoyladenine synthase/serine/threonine protein kinase

Date:
2020-10-26
Family Accession:
NF007174.0
Method:
HMM
11.

Kae1-associated kinase Bud32

Date:
2020-10-26
Family Accession:
NF011462.0
Method:
HMM
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