Protein Family Models

HGAL is a family of mammalian sequences typically between 104 and 179 amino acids in length. Members were discovered in a search for proteins precipitating diffuse large B-cell lymphomas [1,2]. HGAL interacts with the cytoskeleton and aids the activity of interleukin-6 on cell migration [3]. It also modulates the RhoA signalling pathway [4]. [1]. 12509382. HGAL is a novel interleukin-4-inducible gene that strongly. predicts survival in diffuse large B-cell lymphoma.. Lossos IS, Alizadeh AA, Rajapaksa R, Tibshirani R, Levy R;. Blood. 2003;101:433-440.. [2]. 12819018. Two newly characterized germinal center B-cell-associated genes,. GCET1 and GCET2, have differential expression in normal and. neoplastic B cells.. Pan Z, Shen Y, Du C, Zhou G, Rosenwald A, Staudt LM, Greiner TC,. McKeithan TW, Chan WC;. Am J Pathol. 2003;163:135-144.. [3]. 17823310. HGAL, a lymphoma prognostic biomarker, interacts with the. cytoskeleton and mediates the effects of IL-6 on cell migration.. Lu X, Chen J, Malumbres R, Cubedo Gil E, Helfman DM, Lossos IS;. Blood. 2007;110:4268-4277.. [4]. 20844236. HGAL, a germinal center specific protein, decreases lymphoma. cell motility by modulation of the RhoA signaling pathway.. Jiang X, Lu X, McNamara G, Liu X, Cubedo E, Sarosiek KA,. Sanchez-Garcia I, Helfman DM, Lossos IS;. Blood. 2010;116:5217-5227. (from Pfam)

Date:

2024-07-08

The AIDA repeat is found on bacterial autotransporter proteins. As the repeat is short and occurs multiple times, it is likely to be the region of the transporter that acts as the stalk between the beta-barrel inserted into the membrane and the N-terminal head domain. [1]. 15547278. Novel roles for the AIDA adhesin from diarrheagenic Escherichia. coli: cell aggregation and biofilm formation.. Sherlock O, Schembri MA, Reisner A, Klemm P;. J Bacteriol. 2004;186:8058-8065.. [2]. 15950405. Characterization and immuno-detection of AIDA-I adhesin isolated. from porcine Escherichia coli.. Fang Y, Ngeleka M, Middleton DM, Simko E;. Vet Microbiol. 2005;109:65-73.. [3]. 1625582. AIDA-I, the adhesin involved in diffuse adherence of the. diarrhoeagenic Escherichia coli strain 2787 (O126:H27), is. synthesized via a precursor molecule.. Benz I, Schmidt MA;. Mol Microbiol. 1992;6:1539-1546.. [4]. 22466966. Discovery of an archetypal protein transport system in bacterial. outer membranes.. Selkrig J, Mosbahi K, Webb CT, Belousoff MJ, Perry AJ, Wells TJ,. Morris F, Leyton DL, Totsika M, Phan MD, Celik N, Kelly M, Oates. C, Hartland EL, Robins-Browne RM, Ramarathinam SH, Purcell AW,. Schembri MA, Strugnell RA, Henderson IR, Walker D, Lithgow T;. Nat Struct Mol Biol. 2012;19:506-510.. [5]. 15123066. Bugs and the gut: an unstable marriage.. Farthing MJ;. Best Pract Res Clin Gastroenterol. 2004;18:233-239. (from Pfam)

Date:

2024-07-08

Members of this family of proteins may have a role in the beta-catenin-Tcf/Lef signaling pathway, as well as in the process of myelination of the central and peripheral nervous system. Defects in Hyccin are the cause of hypomyelination with congenital cataracts [MIM:610532]. This disorder is characterised by congenital cataracts, progressive neurologic impairment, and diffuse myelin deficiency. Affected individuals experience progressive pyramidal and cerebellar dysfunction, muscle weakness and wasting prevailing in the lower limbs [1][2]. [1]. 16951682. Deficiency of hyccin, a newly identified membrane protein,. causes hypomyelination and congenital cataract.. Zara F, Biancheri R, Bruno C, Bordo L, Assereto S, Gazzerro E,. Sotgia F, Wang XB, Gianotti S, Stringara S, Pedemonte M, Uziel. G, Rossi A, Schenone A, Tortori-Donati P, van der Knaap MS,. Lisanti MP, Minetti C;. Nat Genet. 2006;38:1111-1113.. [2]. 10910037. Isolation and characterization of a novel human gene, DRCTNNB1A,. the expression of which is down-regulated by beta-catenin.. Kawasoe T, Furukawa Y, Daigo Y, Nishiwaki T, Ishiguro H, Fujita. M, Satoh S, Miwa N, Nagasawa Y, Miyoshi Y, Ogawa M, Nakamura Y;. Cancer Res. 2000;60:3354-3358. (from Pfam)

Date:

2024-07-08

potassium channel protein spans the cell membrane to form a conduction pathway or pore, through which potassium ions diffuse according to their electrochemical gradient

Date:

2021-08-23

potassium channel protein spans the cell membrane to form a conduction pathway or pore, through which potassium ions diffuse according to their electrochemical gradient

Date:

2020-02-14

potassium channel protein spans the cell membrane to form a conduction pathway or pore, through which potassium ions diffuse according to their electrochemical gradient

Date:

2018-12-13

potassium channel protein spans the cell membrane to form a conduction pathway or pore, through which potassium ions diffuse according to their electrochemical gradient

Date:

2018-12-13

potassium channel protein spans the cell membrane to form a conduction pathway or pore, through which potassium ions diffuse according to their electrochemical gradient

Date:

2018-12-13

potassium channel protein spans the cell membrane to form a conduction pathway or pore, through which potassium ions diffuse according to their electrochemical gradient

Date:

2022-08-30

potassium channel protein spans the cell membrane to form a conduction pathway or pore, through which potassium ions diffuse according to their electrochemical gradient

Date:

2018-12-13

The Agg4 system (aggregative adherence fimbria 4, AAF/IV) is also known as Hda (HUS-associated diffuse adherence), where HUS is hemolytic uremic syndrome. HdaB, the minor pilin, appears at the pilus tip and is responsible for adhesion.

Gene:

hdaB

Date:

2018-07-11

The Agg4 system (aggregative adherence fimbria 4, AAF/IV) is also known as Hda (HUS-associated diffuse adherence), where HUS is hemolytic uremic syndrome. HdaA, the major pilin, forms most of the length of the pilus, but the minor pilin forms the tip that mediates adhesion. Agg4A/HdaA is related to the M-agglutinin protein.

Gene:

hdaA

Date:

2019-09-26

The Agg4 system (aggregative adherence fimbria 4, AAF/IV) is also known as Hda (HUS-associated diffuse adherence), where HUS is hemolytic uremic syndrome. HdaC is the usher protein for AAF/IV pilus formation.

Gene:

hdaC

Date:

2018-07-11

potassium channel protein spans the cell membrane to form a conduction pathway or pore, through which potassium ions diffuse according to their electrochemical gradient

Date:

2017-02-03

gap junction protein form gap-junctions between cells and contains four transmembrane (TM) regions; one gap junction consists of a cluster of closely packed pairs of TM channels, the connexons, through which materials of low molecular weight diffuse from one cell to a neighboring cell

Date:

2018-11-26

PL2_Passenger_AT domain-containing protein; PL2_Passenger_AT domain-containing protein; autotransporter outer membrane beta-barrel domain-containing protein similar to Escherichia coli autotransporter AIDA-I (adhesin involved in diffuse adherence); autotransporter outer membrane beta-barrel domain-containing protein similar to Escherichia coli uncharacterized protein YaiT and Bordetella pertussis autotransporter BrkA (Bordetella serum-resistance killing protein A); autotransporter outer membrane beta-barrel domain-containing protein similar to Escherichia coli autotransporter AIDA-I (adhesin involved in diffuse adherence); autotransporter outer membrane beta-barrel domain-containing protein similar to Escherichia coli uncharacterized protein YaiT and Bordetella pertussis autotransporter BrkA (Bordetella serum-resistance killing protein A)

Date:

2019-03-21

autotransporter outer membrane beta-barrel domain-containing protein may function as an adhesin that mediates bacterial attachment to host cells, and may play a role in virulence; autotransporter outer membrane beta-barrel domain-containing protein may function as an adhesin that mediates bacterial attachment to host cells, and may play a role in virulence; autotransporter outer membrane beta-barrel domain-containing protein similar to Escherichia coli uncharacterized protein YaiT and Bordetella pertussis autotransporter BrkA (Bordetella serum-resistance killing protein A); autotransporter outer membrane beta-barrel domain-containing protein similar to Escherichia coli uncharacterized protein YaiT and Bordetella pertussis autotransporter BrkA (Bordetella serum-resistance killing protein A); autotransporter outer membrane beta-barrel domain-containing protein similar to Escherichia coli autotransporter AIDA-I (adhesin involved in diffuse adherence); autotransporter outer membrane beta-barrel domain-containing protein similar to Neisseria Meningitidis autotransporter NalP, a virulence-related protein which is secreted via the C-terminal translocator domain; autotransporter outer membrane beta-barrel domain-containing protein similar to Neisseria Meningitidis autotransporter NalP; autotransporter outer membrane beta-barrel domain-containing protein similar to Rickettsia Sca1, an autotransporter protein that evolves under dual evolution pressure; autotransporter outer membrane beta-barrel domain-containing protein similar to Neisseria Meningitidis autotransporter NalP; autotransporter outer membrane beta-barrel domain-containing protein similar to Rickettsia Sca1, an autotransporter protein that evolves under dual evolution pressure

Date:

2019-03-21

Both Aah (autotransporter adhesin heptosyltransferase) and TibC (tib is enterotoxigenic invasion locus B) are protein O-heptosyltransferases that act on multiple sites from repeat regions of proteins exported by autotransporters. Aah glycosylates AIDA, or autotransporter adhesin involved in diffuse adherence, TibC acts on TibA, but TibC can replace Aah.

Date:

2022-01-26