Protein Family Models

The term 3-hydroxyacyl-CoA dehydrogenase, corresponding to EC 1.1.1.35, covers a range of specificities, as the acyl group is not specified. Beta-hydroxyacyl dehydrogenase is a synonym. There may be mulitple members of the family in a single genome, e.g. FadB, FabJ, and PaaH from Escherichia coli K-12.

Date:

2024-08-14

classical SDR (short-chain dehydrogenase/reductase) family NAD(P)-dependent oxidoreductase similar to 3-ketoacyl-ACP reductase (FabG), which catalyzes the reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis; classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue

Date:

2021-08-24

classical SDR (short-chain dehydrogenase/reductase) family NAD(P)-dependent oxidoreductase similar to Sinorhizobium meliloti 3-ketoacyl-ACP reductase (FabG), which catalyzes the reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis; classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue

Date:

2021-08-30

classical SDR (short-chain dehydrogenase/reductase) family NAD(P)-dependent oxidoreductase similar to Sinorhizobium meliloti 3-ketoacyl-ACP reductase (FabG), which catalyzes the reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis; classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue

Date:

2021-08-24

SDR family NAD(P)-dependent oxidoreductase is a short-chain dehydrogenase (SDR) family protein similar to beta-ketoacyl-ACP reductase which catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis

Date:

2018-07-18

classical SDR (short-chain dehydrogenase/reductase) family NAD(P)-dependent oxidoreductase similar to Sinorhizobium meliloti 3-ketoacyl-ACP reductase (FabG), which catalyzes the reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis; classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue

Date:

2021-08-30

classical SDR (short-chain dehydrogenase/reductase) family NAD(P)-dependent oxidoreductase similar to Sinorhizobium meliloti 3-ketoacyl-ACP reductase (FabG), which catalyzes the reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis; classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue

Date:

2021-08-24

classical SDR (short-chain dehydrogenase/reductase) family NAD(P)-dependent oxidoreductase similar to Sinorhizobium meliloti 3-ketoacyl-ACP reductase (FabG), which catalyzes the reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis; classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue

Date:

2021-08-30