Protein Family Models

PatX is a small protein found in heterocyst-forming cyanobacteria. It contributes to maintenance of a vegetative state by opposing differentiation of cells into heterocysts. PatX contains a motif near its C-terminus, RG(S/T)GR, similar the RGSGR found in both PatS and HetN.

Gene:

patX

Date:

2024-08-02

Members of this family are the third in a series glutaredoxin-like proteins, homologous to but distinct from a number of other families in which the last three amino acids are usually UXX but sometimes CXX. In this family, known so far only from uncultured bacteria, the final three amino acids are occassionally UXF but more often [S/T]XF. Note that selenoprotein families in which U replaces S or T instead of C are unusual.

Gene:

uxx3

Date:

2024-07-17

FYN-binding protein 1 acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells

Date:

2024-02-09

armadillo repeat-containing protein 5 (ARMC5) is involved in fetal development, T-cell function and adrenal gland growth homeostasis

Date:

2024-02-09

aminomethyltransferase family protein similar to glycine cleavage system protein T and to Sphingomonas paucimobilis LigM, an O-demethylase that catalyzes a C1-unit transfer from vanillate (VNL) to H4 folate; contains at DUF1989 domain

Date:

2024-02-09

troponin such as troponin I (TnI, inhibitory) and T (TnT, tropomyosin binding) subunits, which together with troponin C (TnC, Ca2+ binding) subunit, form the troponin complex that regulates Ca2+ induced muscle contraction

Date:

2024-02-09

tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD is part of the enzyme complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine; contains a GNAT family N-acetyltransferase that may catalyze the transfer of an acetyl group from acetyl-CoA to a substrate

Date:

2024-02-09

tRNA N6-adenosine threonylcarbamoyltransferase is part of the enzyme complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine

Date:

2024-02-09

tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD is part of the enzyme complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine

Date:

2024-02-09

CENP-X/MHF2 family protein similar to CENP-X histone-fold protein, one of the components of the constitutive centromere-associated network (CCAN) that form CENP-T-W-S-X nucleosome-like complexes and is also involved in kinetochore assembly

Date:

2024-02-09

8-oxo-dGTP diphosphatase is a Nudix family hydrolase that catalyzes the hydrolysis of nucleoside triphosphates such as 8-oxo-dGTP, preventing A:T to C:G and G:C to T:A transversions

Date:

2024-02-09

syntaxin family protein similar to Saccharomyces cerevisiae syntaxin-8, a t-SNARE which may play a role in determining the specificity of membrane fusion, protein transport and vesicle trafficking within the Golgi/endosomal and plasma membrane/endosomal systems

Date:

2024-02-09

chitin binding peritrophin-A domain-containing protein similar to Blomia tropicalis major allergen Blo t 12 and Caenorhabditis elegans chondroitin proteoglycan 1

Date:

2024-02-09

KEOPS complex subunit Cgi121 is a component of the KEOPS (tRNA threonylcarbamoyladenosine modification) complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, a step in the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine

Date:

2024-02-09

This domain represents the polycystin domain from group II of Transient receptor potential (TRP) channels (TRPP) including PKD1, PKD2, PKD2L and mucolipins. The polycystin domain display a sandwich-like shape with five beta-sheets in the tilted middle layer, three alpha-helices on one side and a large loop with two short antiparallel beta-sheets on the other [3]. [1]. 10517637. Polycystin-L is a calcium-regulated cation channel permeable to. calcium ions.. Chen XZ, Vassilev PM, Basora N, Peng JB, Nomura H, Segal Y,. Brown EM, Reeders ST, Hediger MA, Zhou J;. Nature 1999;401:383-386.. [2]. 11264013. Polycystin-2 is a novel cation channel implicated in defective. intracellular Ca(2+) homeostasis in polycystic kidney disease.. Vassilev PM, Guo L, Chen XZ, Segal Y, Peng JB, Basora N,. Babakhanlou H, Cruger G, Kanazirska M, Ye Cp, Brown EM, Hediger. MA, Zhou J;. Biochem Biophys Res Commun 2001;282:341-350.. [3]. 29567962. Cryo-EM structure of the polycystic kidney disease-like channel. PKD2L1.. Su Q, Hu F, Liu Y, Ge X, Mei C, Yu S, Shen A, Zhou Q, Yan C, Lei. J, Zhang Y, Liu X, Wang T;. Nat Commun. 2018;9:1192. (from Pfam)

Date:

2024-08-14

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001740) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide, in particular the phthoxazolin biosynthetic gene cluster from Streptomyces avermitilis [1]. [1]. 29324854. Characterization of the biosynthetic gene cluster for cryptic. phthoxazolin A in Streptomyces avermitilis.. Suroto DA, Kitani S, Arai M, Ikeda H, Nihira T;. PLoS One. 2018;13:e0190973. (from Pfam)

Date:

2024-08-14

Members of this entry are retrotransposon hot spot (RHS) proteins. They are associated with polymorphic subtelomeric regions in Trypanosoma. These proteins contain a conserved box 1 with a P-loop motif and a retrotransposon insertion site at the C-terminal (Pfam:PF07999). This domain represents the N-terminal region of the conserved box 1 from RHSPs [1]. [1]. 12455980. A new, expressed multigene family containing a hot spot for. insertion of retroelements is associated with polymorphic. subtelomeric regions of Trypanosoma brucei.. Bringaud F, Biteau N, Melville SE, Hez S, El-Sayed NM, Leech V,. Berriman M, Hall N, Donelson JE, Baltz T;. Eukaryot Cell 2002;1:137-151. (from Pfam)

Date:

2024-08-14

Date:

2024-08-14

Torsin-1A-interacting proteins 1 and 2 (TOIP 1/2) also known as LAP1 proteins (Lamina-associated polypeptide 1) are type 2 integral membrane proteins with a single membrane-spanning region of the inner nuclear membrane [1,2]. These proteins interact with and activate Torsin A, an AAA+ ATPase localised to the endoplasmic reticulum (ER) through a perinuclear domain, and forms a heterohexameric (LAP1-Torsin)3 ring that targets Torsin to the nuclear envelope. LAP1 has an atypical AAA+ fold and provides an arginine finger to the Torsin A active site to promote its ATPase activity [3,4]. A single mutation in Torsin A causes early onset primary dystonia, a painful and severely disabling neuromuscular disease [3,4]. This entry represents the N-terminal domain of LAP1 which contains transmembrane helices [3,4]. [1]. 12061773. Molecular cloning of one isotype of human lamina-associated. polypeptide 1s and a topological analysis using its deletion. mutants.. Kondo Y, Kondoh J, Hayashi D, Ban T, Takagi M, Kamei Y, Tsuji L,. Kim J, Yoneda Y;. Biochem Biophys Res Commun 2002;294:770-778.. [2]. 7721789. cDNA cloning and characterization of lamina-associated. polypeptide 1C (LAP1C), an integral protein of the inner nuclear. membrane.. Martin L, Crimaudo C, Gerace L;. J Biol Chem 1995;270:8822-8828.. [3]. 25149450. How lamina-associated polypeptide 1 (LAP1) activates Torsin.. Sosa BA, Demircioglu FE, Chen JZ, Ingram J, Ploegh HL, Schwartz. TU;. Elife. 2014;3:e03239.. [4]. 27490483. Structures of TorsinA and its disease-mutant complexed with an. activator reveal the molecular basis for primary dystonia.. Demircioglu FE, Sosa BA, Ingram J, P. TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-08-14

Astrotactin-1 and 2 (ASTN1/2) are integral membrane proteins with a large C-terminal domain, extracellular for ASTN1 and endosome luminal for ASTN-2 [1,2]. They play critical roles in neurodevelopment, and ASTN-2 is also involved in the planar cell polarity pathway in hair cells. This is a domain found in the middle of the C-terminal of ASTN-1 and 2, which comprises a fibronectin type III (Fn(III)) domain [1]. This domain located between the MACPF and annexin domains. The structure of Fn(III) from ASTN2 revealed an unexpected feature which has two additional beta strands folded across the core. The junction between EGF-4 and Fn(III) domains in ASTN2 (but not in ASTN1) is thought to be an inositol triphosphate binding site [1]. Paper describing PDB structure 5j67. [1]. 27249642. Structure of astrotactin-2: a conserved vertebrate-specific and. perforin-like membrane protein involved in neuronal development.. Ni T, Harlos K, Gilbert R;. Open Biol. 2016; [Epub ahead of print]. [2]. 20573900. Astn2, a novel member of the astrotactin gene family, regulates. the trafficking of ASTN1 during glial-guided neuronal migration.. Wilson PM, Fryer RH, Fang Y, Hatten ME;. J Neurosci. 2010;30:8529-8540. (from Pfam)

Date:

2024-08-14