Protein Family Models

This family consists of several mammalian signaling lymphocytic activation molecule (SLAM) proteins. Optimal T cell activation and expansion require engagement of the TCR plus co-stimulatory signals delivered through accessory molecules. SLAM, a 70-kDa co-stimulatory molecule belonging to the Ig superfamily, is defined as a human cell surface molecule that mediates CD28-independent proliferation of human T cells and IFN-gamma production by human Th1 and Th2 clones [1]. SLAM has also been recognised as a receptor for measles virus [2]. [1]. 10570270. Molecular and functional characterization of mouse signaling. lymphocytic activation molecule (SLAM): differential expression. and responsiveness in Th1 and Th2 cells.. Castro AG, Hauser TM, Cocks BG, Abrams J, Zurawski S, Churakova. T, Zonin F, Robinson D, Tangye SG, Aversa G, Nichols KE, de. Vries JE, Lanier LL, O'Garra A;. J Immunol 1999;163:5860-5870.. [2]. 12610126. Measles virus infects and suppresses proliferation of T. lymphocytes from transgenic mice bearing human signaling. lymphocytic activation molecule.. Hahm B, Arbour N, Naniche D, Homann D, Manchester M, Oldstone. MB;. J Virol 2003;77:3505-3515. (from Pfam)

Date:

2024-07-08

Surface lipoprotein assembly modifier (Slam) is a surface lipoprotein that may have a role in virulence [1]. In Neisseria, it is required for the surface display of lipidated virulence factors [2]. Proteins in this family contain an eight-stranded beta-barrel domain [1]. [1]. 28620585. Identification of a Large Family of Slam-Dependent Surface. Lipoproteins in Gram-Negative Bacteria.. Hooda Y, Lai CCL, Moraes TF;. Front Cell Infect Microbiol. 2017;7:207.. [2]. 27572441. Slam is an outer membrane protein that is required for the. surface display of lipidated virulence factors in Neisseria.. Hooda Y, Lai CC, Judd A, Buckwalter CM, Shin HE, Gray-Owen SD,. Moraes TF;. Nat Microbiol. 2016;1:16009. (from Pfam)

Date:

2024-07-08

Date:

2023-04-01

Ig_SLAM-like_N and Ig_2 domain-containing protein

Date:

2017-03-02

Ig_SLAM-like_N and Ig_3 domain-containing protein

Date:

2017-03-02

Ig_SLAM-CD84_like_N and Ig_3 domain-containing protein

Date:

2017-03-02

Ig_SLAM-CD84_like_N domain-containing protein

Date:

2017-03-02

Ig_3 and Ig_SLAM-like_N domain-containing protein

Date:

2017-03-02

Ig_SLAM-like_N and Ig domain-containing protein

Date:

2017-03-02

SLAM domain-containing protein

Date:

2017-03-02