Protein Family Models

Bsa (bacteriocin of S. aureus) is a lantibiotic related to epidermin. BsaG is an apparent immunity protein to Bsa and probably to other lantibiotics closely related to Bsa.

Date:

2024-09-21

AryK is a AraC/XylS family transcriptional regulator in the genus Streptococcus. In S. aureus, AryK affects virulance factor gene expression and toxin production. Orthologs in other staphylococcal species may be quite difference in sequence, and their role is not well characterized.

Gene:

aryK

Date:

2024-08-17

PatX is a small protein found in heterocyst-forming cyanobacteria. It contributes to maintenance of a vegetative state by opposing differentiation of cells into heterocysts. PatX contains a motif near its C-terminus, RG(S/T)GR, similar the RGSGR found in both PatS and HetN.

Gene:

patX

Date:

2024-08-02

Members of this family are the third in a series glutaredoxin-like proteins, homologous to but distinct from a number of other families in which the last three amino acids are usually UXX but sometimes CXX. In this family, known so far only from uncultured bacteria, the final three amino acids are occassionally UXF but more often [S/T]XF. Note that selenoprotein families in which U replaces S or T instead of C are unusual.

Gene:

uxx3

Date:

2024-07-17

DNA cytosine methyltransferase catalyzes methyl transfer from the donor co-factor S-adenosylmethionine to C5 of the target cytosine

Date:

2024-02-09

glycosyltransferase family 8 protein containing a class I SAM-dependent methyltransferase domain, catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds, and possibly the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Date:

2024-02-09

bifunctional GNAT family N-acetyltransferase/class I SAM-dependent methyltransferase containing an N-terminal domain that may catalyze the transfer of an acetyl group from acetyl-CoA to a substrate, and a C-terminal class I SAM-dependent methyltransferase domain that may catalyze the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Date:

2024-02-09

peptide-methionine (R)-S-oxide reductase catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins

Date:

2024-02-09

cell wall-binding repeat-containing protein similar to Clostridium difficile S-layer protein SlpA, cell wall protein V (CwpV), and Cwp66; the cell wall binding repeat 2 is found in mutiple copies in proteins

Date:

2024-02-09

sortase is a cysteine transpeptidase that cleaves a substrate protein at a conserved cell wall sorting signal and covalently links it to peptidoglycan; contains N-terminal S-layer homology domains

Date:

2024-02-09

SLH (S-layer homology) domain-containing protein similar to S-layer proteins that are major cell-wall components which form a paracrystalline mono-layered assembly that coats the surface of bacteria

Date:

2024-02-09

class I SAM-dependent methyltransferase that catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to eukaryotic NADH dehydrogenase complex I assembly factor 7, which is involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex

Date:

2024-02-09

peptide-methionine (R)-S-oxide reductase catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins

Date:

2024-02-09

class I SAM-dependent methyltransferase that catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Date:

2024-02-09

S-adenosyl-L-methionine (SAM)-dependent methyltransferase similar to the mammalian protein RRNAD1, which is associated with periodontal disease

Date:

2024-02-09

class I SAM-dependent methyltransferase that catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Date:

2024-02-09

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Date:

2024-02-09

SLH (S-layer homology) domain-containing protein similar to S-layer proteins that are major cell-wall components which form a paracrystalline mono-layered assembly that coats the surface of bacteria

Date:

2024-02-09

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing protein may function as a protein-lysine N-methyltransferase, catalyzing the S-adenosyl-L-methionine (SAM)-dependent methylation at specific lysine residues of target proteins such as histones

Date:

2024-02-09

SpoU family RNA methyltransferase catalyzes the methylation of rRNA or tRNA at specific sites in a S-adenosyl-L-methionine (SAM)-dependent manner

Date:

2024-02-09