Protein Family Models

This receptor consists of 796 amino acids and can be divided in the extracellular ligand-binding domain, the trans-membrane domain, and the intracellular tyrosine kinase domain [1].This domain is the TMD of TrkA which has shown to be involved in the interaction with amyloid precursor protein (APP) [2]. [1]. 28039433. Structural characterization of nonactive site, TrkA-selective. kinase inhibitors.. Su HP, Rickert K, Burlein C, Narayan K, Bukhtiyarova M, Hurzy. DM, Stump CA, Zhang X, Reid J, Krasowska-Zoladek A, Tummala S,. Shipman JM, Kornienko M, Lemaire PA, Krosky D, Heller A, Achab. A, Chamberlin C, Saradjian P, Sauvagnat B, Yang X, Ziebell MR,. Nickbarg E, Sanders JM, Bilodeau MT, Carroll SS, Lumb KJ,. Soisson SM, Henze DA, Cooke AJ;. Proc Natl Acad Sci U S A. 2017;114:E297.. [2]. 28197073. Association of TrkA and APP Is Promoted by NGF and Reduced by. Cell Death-Promoting Agents.. Canu N, Pagano I, La Rosa LR, Pellegrino M, Ciotti MT, Mercanti. D, Moretti F, Sposato V, Triaca V, Petrella C, Maruyama IN, Levi. A, Calissano P;. Front Mol Neurosci. 2017;10:15. (from Pfam)

Date:

2024-04-03

Quaking_NLS is the very C-terminal region of quaking proteins that is purported to be the nuclear localisation signal [1,2]. [1]. 8589716. The quaking gene product necessary in embryogenesis and. myelination combines features of RNA binding and signal. transduction proteins.. Ebersole TA, Chen Q, Justice MJ, Artzt K;. Nat Genet. 1996;12:260-265.. [2]. 21447554. Fine-tuning of Hh signaling by the RNA-binding protein Quaking. to control muscle development.. Lobbardi R, Lambert G, Zhao J, Geisler R, Kim HR, Rosa FM;. Development. 2011;138:1783-1794. (from Pfam)

Date:

2024-04-03

This domain is a heme binding cytochrome known as cytochrome c550, or cytochrome c549, or PsbV [1]. [1]. 11315568. Crystal structure of low-potential cytochrome c549 from. Synechocystis sp. PCC 6803 at 1.21 A resolution.. Frazao C, Enguita FJ, Coelho R, Sheldrick GM, Navarro JA, Hervas. M, De la Rosa MA, Carrondo MA;. J Biol Inorg Chem. 2001;6:324-332. (from Pfam)

Date:

2024-04-03

This entry represents the N-terminal domain of beta-fructofuranosidase, which is involved in the hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides [1]. [1]. 27083698. RhVI1 is a membrane-anchored vacuolar invertase highly expressed. in Rosa hybrida L. petals.. Farci D, Collu G, Kirkpatrick J, Esposito F, Piano D;. J Exp Bot. 2016;67:3303-3312. (from Pfam)

Date:

2024-04-03

The proteins featured in this family are all eukaryotic, and many of them are annotated as being Gryzun. Gryzun is distantly related to, but distinct from, the Trs130 subunit of the TRAPP complex but is absent from S. cerevisiae. RNAi of human Gryzun (Swiss:Q7Z392) blocks Golgi exit. Thus the family is likely to be involved with trafficking of proteins through membranes, perhaps as part of the TRAPP complex. [1]. 19942856. A genome-wide RNA interference screen identifies two novel. components of the metazoan secretory pathway.. Wendler F, Gillingham AK, Sinka R, Rosa-Ferreira C, Gordon DE,. Franch-Marro X, Peden AA, Vincent JP, Munro S;. EMBO J. 2009; [Epub ahead of print] (from Pfam)

Date:

2024-04-03

This entry represents zeta-subunits, which are found in alpha-proteobacterial F1F0-ATPase regulatory proteins. The zeta subunit is a potent inhibitor of the alpha-proteobacterial F1FO-ATPase. The inhibitory region resides in the first 14 N-terminal residues of the protein, which protrude from the 4-alpha-helix bundle structure of the isolated zeta subunit [1, 2, 3]. [1]. 24522203. The zeta subunit of the F1FO-ATP synthase of. alpha-proteobacteria controls rotation of the nanomotor with a. different structure.. Zarco-Zavala M, Morales-Rios E, Mendoza-Hernandez G,. Ramirez-Silva L, Perez-Hernandez G, Garcia-Trejo JJ;. FASEB J. 2014;28:2146-2157.. [2]. 19783785. A novel 11-kDa inhibitory subunit in the F1FO ATP synthase of. Paracoccus denitrificans and related alpha-proteobacteria.. Morales-Rios E, de la Rosa-Morales F, Mendoza-Hernandez G,. Rodriguez-Zavala JS, Celis H, Zarco-Zavala M, Garcia-Trejo JJ;. FASEB J. 2010;24:599-608.. [3]. 24838125. NMR structures of alpha-proteobacterial ATPase-regulating. zeta-subunits.. Serrano P, Geralt M, Mohanty B, Wuthrich K;. J Mol Biol. 2014;426:2547-2553. (from Pfam)

Date:

2024-04-03

This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states [1]. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway [2,3]. [1]. 17994020. Mutations in LMF1 cause combined lipase deficiency and severe. hypertriglyceridemia.. Peterfy M, Ben-Zeev O, Mao HZ, Weissglas-Volkov D, Aouizerat BE,. Pullinger CR, Frost PH, Kane JP, Malloy MJ, Reue K, Pajukanta P,. Doolittle MH;. Nat Genet. 2007;39:1483-1487.. [2]. 20543905. Mechanisms of lipase maturation.. Doolittle MH, Peterfy M;. Clin Lipidol. 2010;5:71-85.. [3]. 24909692. Purification, cellular levels, and functional domains of lipase. maturation factor 1.. Babilonia-Rosa MA, Neher SB;. Biochem Biophys Res Commun. 2014;450:423-428. (from Pfam)

Date:

2024-04-03

S. cerevisiae Spo7 Swiss:P18410 has an unknown function, but has a role in formation of a spherical nucleus and meiotic division [1]. [1]. 9822591. A novel complex of membrane proteins required for formation of a. spherical nucleus.. Siniossoglou S, Santos-Rosa H, Rappsilber J, Mann M, Hurt E;. EMBO J 1998;17:6449-6464.. [2]. 2253888. Molecular cloning of chromosome I DNA from Saccharomyces. cerevisiae: isolation, characterization and regulation of the. SPO7 sporulation gene.. Whyte W, Keopp LH, Lamb J, Crowley JC, Kaback DB;. Gene 1990;95:65-72. (from Pfam)

Date:

2024-04-03

This family consists of conserved hypothetical proteins from Borrelia burgdorferi the lyme disease spirochaete, some of which are putative plasmid partition proteins [1]. [1]. 9695920. Evidence of past recombination events among the genes encoding. the Erp antigens of Borrelia burgdorferi.. Stevenson B, Casjens S, Rosa P;. Microbiology 1998;144:1869-1879.. [2]. 8655548. A family of genes located on four separate 32-kilobase circular. plasmids in Borrelia burgdorferi B31.. Stevenson B, Tilly K, Rosa PA;. J Bacteriol 1996;178:3508-3516. (from Pfam)

Date:

2024-04-03

This is a family of outer surface proteins (Osp) from the Borrelia spirochete [1]. The family includes OspE, and OspEF-related proteins (Erp) [2,3]. These proteins are coded for on different circular plasmids in the Borrelia genome. [1]. 8982001. Homology throughout the multiple 32-kilobase circular plasmids. present in Lyme disease spirochetes.. Casjens S, van Vugt R, Tilly K, Rosa PA, Stevenson B;. J Bacteriol 1997;179:217-227.. [2]. 8655548. A family of genes located on four separate 32-kilobase circular. plasmids in Borrelia burgdorferi B31.. Stevenson B, Tilly K, Rosa PA;. J Bacteriol 1996;178:3508-3516.. [3]. 19001079. Borrelia burgdorferi infection-associated surface proteins ErpP,. ErpA, and ErpC bind human plasminogen.. Brissette CA, Haupt K, Barthel D, Cooley AE, Bowman A, Skerka C,. Wallich R, Zipfel PF, Kraiczy P, Stevenson B;. Infect Immun. 2009;77:300-306. (from Pfam)

Date:

2024-04-03

Several members of this family are Borrelia burgdorferi plasmid proteins of uncharacterized function. [1]. 10672174. A bacterial genome in flux: the twelve linear and nine circular. extrachromosomal DNAs in an infectious isolate of the Lyme. disease spirochete Borrelia burgdorferi.. Casjens S, Palmer N, van Vugt R, Huang WM, Stevenson B, Rosa P,. Lathigra R, Sutton G, Peterson J, Dodson RJ, Haft D, Hickey E,. Gwinn M, White O, Fraser CM;. Mol Microbiol 2000;35:490-516. (from Pfam)

Date:

2024-04-03

Zn(II)2Cys6 transcription factor domain-containing proteins form a subclass of zinc finger proteins found exclusively in fungi and yeast.

Date:

2019-11-26

cinnamyl-alcohol dehydrogenase family protein similar to Rosa hybrid cultivar phenylacetaldehyde reductase and Medicago truncatula dihydroflavonol-4-reductase

Date:

2021-09-02

This rare enzyme, a SAM-dependent methyltransferase, catalyzes a pair of methyl additions to complete the synthesis of roseoflavin, a riboflavin analog antibiotic. The first committed step of roseoflavin biosynthesis is catalyzed by RosB.

Gene:

rosA

Date:

2018-01-16