Protein Family Models

This domain is found on the N-terminus of the viral protein D10 (VD10) and the related MutT motif proteins [2]. The VD10 protein is probably essential for virus replication [1] and is often found to the N-terminus of a Pfam:PF00293 domain. [1]. 2177083. Analysis of the fowlpox virus genome region corresponding to the. vaccinia virus D6 to A1 region: location of, and variation in,. non-essential genes in poxviruses.. Binns MM, Britton BS, Mason C, Boursnell ME;. J Gen Virol 1990;71:2873-2881.. [2]. 9847390. Down regulation of gene expression by the vaccinia virus D10. protein.. Shors T, Keck JG, Moss B;. J Virol 1999;73:791-796. (from Pfam)

Date:

2024-08-14

This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains [1]. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained [2]. [1]. 7866389. Molecular characterization of a cytoplasmic dynein from. Dictyostelium.. Koonce MP, Grissom PM, Lyon M, Pope T, McIntosh JR;. J Eukaryot Microbiol 1994;41:645-651.. [2]. 11250194. Model for the motor component of dynein heavy chain based on. homology to the AAA family of oligomeric ATPases.. Mocz G, Gibbons IR;. Structure. 2001;9:93-103. (from Pfam)

Date:

2024-08-14

Nrap_D6 domain-containing protein

Date:

2019-03-21

protein containing domains Nrap, Nrap_D2, Nrap_D3, and Nrap_D6

Date:

2019-03-21

protein containing domains Nrap_D2, Nrap_D4, Nrap_D5, and Nrap_D6

Date:

2019-03-21

protein containing domains Nrap_D3, Nrap_D4, Nrap_D5, and Nrap_D6

Date:

2019-03-21