Protein Family Models

The two-component system of sensor histidine kinase LIC_11548 and response regulator LIC_11549 is conserved across the genus Leptospira. It resembles the system of nitrate sensor histitdine kinase NtrY and response regulator NtrX, but the actual role has not been established. A full-length homolog exists in Leptonema, but cutoffs are set such that it scores in the gray zone between the gathering threshold and the noise cutoff in case the specific function differs.

Date:

2024-09-04

This BlastRule describes a currently unnamed member of the Len (Leptospira ENdostatin-like) family of outer membrane proteins, which has named members LenA through LenF. This family is a full length homolog of LenD, but only about 30 percent identical.

Gene:

len

Date:

2024-08-21

Members of this family, named YmfI after the founding member from Bacillus subtilis, are restricted to bacterial species in which the post-translational modification of elongation factor P (EF-P) is 5-aminopentanol at Lys-32. This protein, a homolog of the 3-keto-acyl ACP reductase FabG, reduces EF-P 5-aminopentanone to EF-P 5-aminopentanol. All 427 members of the seed alignment are from species in which YmfF and YmfH homologs are encoded by an adjacent gene pair.

Gene:

ymfI

Date:

2024-08-06

pygopus homolog 2 (PYGO2) functions as a context-dependent beta-catenin coactivator, as well as a histone methylation reader that binds di-and trimethylated lysine 4 of histone H3 (H3K4me2/3)

Date:

2024-02-09

disks large homolog 1 is an essential multidomain scaffolding protein required for normal development

Date:

2024-02-09

VEPH1 family Pleckstrin homology (PH) domain-containing protein similar to mammalian ventricular zone-expressed PH domain-containing protein homolog 1, also known as protein melted, which interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling

Date:

2024-02-09

TraB/VirB10 family protein forms part of core complex in Type IV secretion system; TraB is a VirB10 homolog and a component of the type IV secretion system (T4SS)

Date:

2024-02-09

DnaJ homolog subfamily C member 2 (DNAJC2) acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus

Date:

2024-02-09

TraB/VirB10 family protein forms part of core complex in Type IV secretion system; TraB is a VirB10 homolog and a component of the type IV secretion system (T4SS)

Date:

2024-02-09

VPS11 family protein similar to Dictyostelium discoideum vacuolar protein sorting-associated protein 11 homolog that may play a role in vesicle-mediated protein trafficking

Date:

2024-02-09

RNA binding protein fox-1 homolog is an RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements

Date:

2024-02-09

TldD/PmbA family protein similar to Sulfolobus solfataricus zinc metalloprotease TldD homolog

Date:

2024-02-09

DsbC family protein such as the DsbC/DsbG homolog DsbP, which is a novel domain-swapped dimeric protein-disulfide isomerase encoded by the multidrug resistance IncA/C transferable plasmid and is associated with conjugation

Date:

2024-02-09

DnaJ homolog subfamily C member 2 (DNAJC2) acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus

Date:

2024-02-09

DnaJ homolog subfamily C member 2 (DNAJC2) family protein similar to mammalian DNAJC2 that acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus

Date:

2024-02-09

VPS11 family protein similar to Dictyostelium discoideum vacuolar protein sorting-associated protein 11 homolog that may play a role in vesicle-mediated protein trafficking

Date:

2024-02-09

TraB/VirB10 family protein forms part of core complex in Type IV secretion system; TraB is a VirB10 homolog and a component of the type IV secretion system (T4SS)

Date:

2024-02-09

TraB/VirB10 family protein forms part of core complex in Type IV secretion system; TraB is a VirB10 homolog and a component of the type IV secretion system (T4SS)

Date:

2024-02-09

RNA binding protein fox-1 homolog is an RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements

Date:

2024-02-09

transcription factor TFIIIB Bdp1 subunit family protein contains a SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain; similar to transcription factor TFIIIB component B'' homolog (Bdp1), a component of the TFIIIB complex that is required for RNA polymerase III transcription

Date:

2024-02-09