Protein Family Models

This roughly 80-amino acid domain belongs to the clan of ATP-binding domains with the Walker A motif (P-loop). It starts and ends with well-conserved alpha-helical regions, interrupted by a region of beta-strands that are prone to insertions of additional sequence. In a large fraction of members, the critical lysine (K) of the P-loop motif GxxGxGK[ST] is replaced by phenylalanine (F), making the function of the motif in those family members unclear. This domain tends to occur as a N-terminal domain of proteins that average over 1000 amino acids in length, such as the human protein sacsin.

Date:

2024-07-26

F-box protein containing a TRAF-like zinc-finger, may function as the substrate-recognition component of a SCF (Skp1-Cullin-F-box protein) ubiquitin-protein ligase that is involved in ubiquitin-dependent degradation

Date:

2024-02-09

F-box protein is the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Date:

2024-02-09

cation-translocating P-type ATPase is an integral membrane transporter that generates and maintains electrochemical gradients across cellular membranes by translocating cations or heavy metals, and is distinguished from other transport ATPases (F-, V-, and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle

Date:

2024-02-09

F0F1 ATP synthase subunit alpha is part of the catalytic core of the F-ATPase that uses a proton gradient to drive ATP synthesis and hydrolyzes ATP to build the proton gradient and is found in bacterial, mitochondrial, and chloroplast membranes

Date:

2024-02-09

type II secretion system (T2SS) F family protein similar to Aggregatibacter actinomycetemcomitans TadB, which is required for tight adherence to surfaces

Date:

2024-02-09

cation-translocating P-type ATPase is an integral membrane transporter that generates and maintains electrochemical gradients across cellular membranes by translocating cations or heavy metals, and is distinguished from other transport ATPases (F-, V-, and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle

Date:

2024-02-09

cation-translocating P-type ATPase is an integral membrane transporter that generates and maintains electrochemical gradients across cellular membranes by translocating cations or heavy metals, and is distinguished from other transport ATPases (F-, V-, and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle

Date:

2024-02-09

heavy metal translocating P-type ATPase is an integral membrane transporter that generates and maintains electrochemical gradients across cellular membranes by translocating heavy metals such as cadmium, zinc and cobalt, and is distinguished from other transport ATPases (F-, V-, and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle

Date:

2024-02-09

F-box protein may function as the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Date:

2024-02-09

cation-translocating P-type ATPase is an integral membrane transporter that generates and maintains electrochemical gradients across cellular membranes by translocating cations or heavy metals, and is distinguished from other transport ATPases (F-, V-, and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle

Date:

2024-02-09

type II secretion system (T2SS) F family protein may play a role in nonspecific adherence to surfaces; similar to similar to Aggregatibacter actinomycetemcomitans TadC, which is required for tight adherence to surfaces

Date:

2024-02-09

type II secretion system (T2SS) F family protein similar to Aggregatibacter actinomycetemcomitans TadB, which is required for tight adherence to surfaces

Date:

2024-02-09

ComF family protein is a predicted amidophosphoribosyltransferase; similar to Haemophilus influenzae competence protein F, which is involved in DNA transformation

Date:

2024-02-09

F0F1 ATP synthase subunit alpha is part of the catalytic core of the F-ATPase that uses a proton gradient to drive ATP synthesis and hydrolyzes ATP to build the proton gradient and is found in bacterial, mitochondrial, and chloroplast membranes

Date:

2024-02-09

F-BAR (FES-CIP4 homology and Bin/Amphiphysin/Rvs) and double SH3 (Src homology 3) domains protein 1 (FCHSD1) promotes actin polymerization mediated by SNX9 and WASL

Date:

2024-02-09

F-BAR (FES-CIP4 homology and Bin/Amphiphysin/Rvs) and double SH3 (Src homology 3) domains protein 1 (FCHSD1) promotes actin polymerization mediated by SNX9 and WASL

Date:

2024-02-09

type II secretion system (T2SS) F family protein similar to Aggregatibacter actinomycetemcomitans TadB, which is required for tight adherence to surfaces

Date:

2024-02-09

F-box only protein 9 (FBXO9) is the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling

Date:

2024-02-09

exocyst complex component Sec10 family protein containing an F-box domain

Date:

2024-02-09