Protein Family Models

F-box protein containing a TRAF-like zinc-finger, may function as the substrate-recognition component of a SCF (Skp1-Cullin-F-box protein) ubiquitin-protein ligase that is involved in ubiquitin-dependent degradation

Date:

2024-02-09

F-box protein is the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Date:

2024-02-09

F-box protein may function as the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Date:

2024-02-09

F-box only protein 9 (FBXO9) is the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling

Date:

2024-02-09

exocyst complex component Sec10 family protein containing an F-box domain

Date:

2024-02-09

TIP120 domain-containing protein similar to Candida albicans cullin-associated NEDD8-dissociated protein 1 (CAND1), also called TBP-interacting protein 120 homolog (TIP120), a key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes

Date:

2024-02-09

This is a family of uncharacterised proteins of unknown function found in viruses. These proteins are thought to include F-box domain containing proteins, a conserved domain present in numerous proteins, involved in protein- protein interaction. (from Pfam)

Date:

2024-08-14

The F-box protein Transport inhibitor response 1 (TIR1) is a receptor for auxin, triggering an auxin-enhanced and ubiquitin-mediated degradation of substrates [1]. The targets are recruited via interaction with the leucine-rich repeat region of the protein. This Pfam entry represents a specific unit of the LRR region, including an insertion of one short alpha-helix in the loop between the beta-strand and the following helix. It shares some sequence homology with a unit with similar structure of Coronatine-insensitive protein 1 [2]. [1]. 18391211. Small-molecule agonists and antagonists of F-box. protein-substrate interactions in auxin perception and. signaling.. Hayashi K, Tan X, Zheng N, Hatate T, Kimura Y, Kepinski S,. Nozaki H;. Proc Natl Acad Sci U S A. 2008;105:5632-5637.. [2]. 20927106. Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ. co-receptor.. Sheard LB, Tan X, Mao H, Withers J, Ben-Nissan G, Hinds TR,. Kobayashi Y, Hsu FF, Sharon M, Browse J, He SY, Rizo J, Howe GA,. Zheng N;. Nature. 2010;468:400-405. (from Pfam)

Date:

2024-08-14

This entry represents the leucine-rich repeats (LRR) from F-box/LRR repeat protein 18 (also known as F-box and leucine-rich repeat protein 18, FBXL18), associated with F-box domains. This protein is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex through its F-box [1] and the LRR motifs mediate the protein-protein interactions required for the binding of the specific substrates by SCFs complexes [2]. [1]. 9346238. F-box proteins are receptors that recruit phosphorylated. substrates to the SCF ubiquitin-ligase complex.. Skowyra D, Craig KL, Tyers M, Elledge SJ, Harper JW;. Cell. 1997;91:209-219.. [2]. 10581972. The F-box: a new motif for ubiquitin dependent proteolysis in. cell cycle regulation and signal transduction.. Craig KL, Tyers M;. Prog Biophys Mol Biol. 1999;72:299-328. (from Pfam)

Date:

2024-08-14

This entry represents the cell cycle link protein Clink from Banana bunchy top virus (BBTV) [1] which was identified as a suppressor of RNA silencing. It interacts with retinoblastoma-related proteins (pRB) and S-phase kinase-associated protein 1 (SKP1). Clink contains LxCxE and F-box motifs that mediate the interactions with the respective proteins and the capacity of Clink to bind pRB correlates with its ability to stimulate viral replication. pRB is a key cell cycle regulator, which represses onset and progression into S-phase by interacting with a wide range of cell cycle-related proteins. [1]. 21161359. Identification of a major pathogenicity determinant and. suppressors of RNA silencing encoded by a South Pacific isolate. of Banana bunchy top virus originating from Pakistan.. Amin I, Ilyas M, Qazi J, Bashir R, Yadav JS, Mansoor S, Fauquet. CM, Briddon RW;. Virus Genes. 2011;42:272-281. (from Pfam)

Date:

2024-08-14

Jasmonates are a family of plant hormones that regulate plant growth, development and responses to stress. COI1 is an F-box protein that functions as the substrate-recruiting module of the Skp1-Cul1-F-box protein (SCF) ubiquitin E3 ligase complex. The role of COI1-mediated JAZ degradation in jasmonate (JA) signaling is analogous to auxin signaling through the receptor F-box protein transport inhibitor response 1 (TIR1) , which promotes hormone-dependent turnover of the AUX/IAA transcriptional repressors. The crystal structure of COI1 reveals a TIR1-like overall architecture, with an N-terminal tri-helical F-box motif bound to ASK1 and a C-terminal horseshoe-shaped solenoid domain formed by 18 tandem leucine-rich repeats. This entry represents the N-terminal F-box domain which is also found in other auxin signaling f-box proteins such as AFB1, AFB2 and AFB3 [1]. [1]. 20927106. Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ. co-receptor.. Sheard LB, Tan X, Mao H, Withers J, Ben-Nissan G, Hinds TR,. Kobayashi Y, Hsu FF, Sharon M, Browse J, He SY, Rizo J, Howe GA,. Zheng N;. Nature. 2010;468:400-405. (from Pfam)

Date:

2024-08-14

This entry represents the C-terminal region of several F-box only proteins. These proteins are the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. This family includes yeast HRT3 protein as well as human F-box only 9 protein. (from Pfam)

Date:

2024-08-14

cNMPbd_u2 is a natively unstructured region on a set of higher eukaryote cyclic nucleotide-binding domain-containing proteins. It lies between the second cNMP_binding, Pfam:PF00027, and the F-box, Pfam:PF00646, domains. The function is not known but there is a highly conserved DPDPFL sequence motif. (from Pfam)

Date:

2024-08-14

Date:

2024-08-14

PI31 is a regulatory subunit of the immuno-proteasome which is an inhibitor of the 20 S proteasome in vitro.PI31 is also an F-box protein Fbxo7.Skp1 binding partner which requires an N terminal FP domain in both proteins for the interaction to occur via the FP beta sheets. The structure of PI31 FP domain contains a novel alpha/beta-fold and two intermolecular contact surfaces [1]. This is the N-terminal domain of the members. [1]. 18495667. Structure of a conserved dimerization domain within the F-box. protein Fbxo7 and the PI31 proteasome inhibitor.. Kirk R, Laman H, Knowles PP, Murray-Rust J, Lomonosov M, Meziane. el K, McDonald NQ;. J Biol Chem. 2008;283:22325-22335. (from Pfam)

Date:

2024-08-14

This is an F-box-like family. (from Pfam)

Date:

2024-08-14

The velvet factor is conserved in many fungal species and is found to have gained different roles depending on the organism's need, expanding the conserved role in developmental programmes [1]. The velvet factor orthologues can be adapted to the fungal-specific life cycle and may be involved in diverse functions such as sclerotia formation and toxin production, as in A. parasiticus [2], nutrition-dependent sporulation, as in A. fumigatus [3], or the microconidia-to-macroconidia ratio and cell wall formation, as in the heterothallic fungus Fusarium verticilloides [[4]. [1]. 17631397. Neurospora crassa ve-1 affects asexual conidiation.. Bayram O, Krappmann S, Seiler S, Vogt N, Braus GH;. Fungal Genet Biol. 2008;45:127-138.. [2]. 15294809. veA is required for toxin and sclerotial production in. Aspergillus parasiticus.. Calvo AM, Bok J, Brooks W, Keller NP;. Appl Environ Microbiol. 2004;70:4733-4739.. [3]. 16824096. The Aspergillus nidulans F-box protein GrrA links SCF activity. to meiosis.. Krappmann S, Jung N, Medic B, Busch S, Prade RA, Braus GH;. Mol Microbiol. 2006;61:76-88.. [4]. 17054442. FvVE1 regulates filamentous growth, the ratio of microconidia to. macroconidia and cell wall formation in Fusarium. verticillioides.. Li S, Myung K, Guse D, Donkin B, Proctor RH, Grayburn WS, Calvo. AM;. Mol Microbiol. 2006;62:1418-1432. (from Pfam)

Date:

2024-08-14

This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with Pfam:PF00646, Pfam:PF00400. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerisation of the protein. Dimerisation is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation. (from Pfam)

Date:

2024-08-14

This region is found in F-box (Pfam:PF00646) and other domain containing plant proteins; it is repeated in two family members. Its precise function is unknown, but it is thought to be associated with nuclear processes [1]. In fact, several family members are annotated as being similar to transcription factors. [1]. 11779830. Systematic identification of novel protein domain families. associated with nuclear functions.. Doerks T, Copley RR, Schultz J, Ponting CP, Bork P;. Genome Res 2002;12:47-56. (from Pfam)

Date:

2024-08-14

This presumed domain is found at the C-terminus of a variety of Pox virus proteins. The PRANC (Pox proteins Repeats of ANkyrin - C terminal) domain is also found on its own in some proteins. The function of this domain is unknown, but it appears to be related to the F-box domain and may play a similar role. [1]. 16025237. F-box-like domains are present in most poxvirus ankyrin repeat. proteins.. Mercer AA, Fleming SB, Ueda N;. Virus Genes. 2005;31:127-133. (from Pfam)

Date:

2024-08-14