Protein Family Models

Gene:

lsa16

Date:

2024-09-19

This HMM describes coenzyme PQQ biosynthesis protein B, a gene required for the biosynthesis of pyrrolo-quinoline-quinone (coenzyme PQQ). PQQ is required for some glucose dehydrogenases and alcohol dehydrogenases. Note that this gene appears to be required for PQQ in biosynthesis in Methylobacterium extorquens (under the name pqqG) and in Klebiella pneumoniae but that the equivalent pqqV in Acinetobacter calcoaceticus is not necessary for heterologous expression of PQQ biosynthesis in E. coli. Based on this latter finding, it is suggested (Goosen, et al. 1989) that PqqB might be a transporter or a PQQ-dependent enzyme rather than a PQQ biosynthesis enzyme.

Gene:

pqqB

Date:

2024-08-23

Date:

2024-08-22

LenE, (Leptospira endostatin-like protein E), like all Len family proteins, is a surface-exposed protein with DUF1554 domain (see PF07588). LenE has two copies of the domain.

Gene:

lenE

Date:

2024-08-21

LIC12587 is a surface-exposed lipoprotein from Leptospira interrogans. It was shown to bind E-cadherin and laminin, suggesting a role in adhesion to host epithelial cells.

Date:

2024-08-20

Members of this family, found exclusively in spirochetes, found exclusively in spirochetes, provide the peptidoglycan lysis necessary for proper assembly of periplasmic type (i.e. spirochete type) flagella. This is one of two functions performed in other species by a bifunctional FlgJ. In spirochetes with this family, FlgJ exists but is monofunctional.

Date:

2024-07-26

Members of this family, found only spirochetes, are the collar protein FlbB of periplasmic-type (i.e. spirochete-type) flagella. Note that the term FlbB is used in other lineages to describe a flagellar transcriptional activator unrelated to this protein.

Date:

2024-07-25

Members of this staphylococcal lipase family have an N-terminal YSIRK-type signal peptide that is known for targeting sortase-dependent (LPXTG motif-containing) cell wall proteins to the cross-wall of growing and dividing cells. However, YSIRK also occurs on proteins that associate with the cell surface through other means. The YSIRK region is followed by a long, variable length low-complexity region rich in Ser, Thr, Asn, Asp, Glu, and Gln, followed by the lipase domain. Genes for member of this family in Staphylococcus aureus may be given as lip1 (e.g. YP_501455.1) and lip2 (YP_498890.1), or gehA and gehB. Members of this family in Staphylococcus aureus are considered virulence factors.

Gene:

lip

Date:

2024-07-22

PD-(D/E)XK nuclease family protein similar to uncharacterized Fromanvirus gene 69 protein

Date:

2024-02-09

PP2C family protein-serine/threonine phosphatase similar to stage II sporulation protein E (SpoIIE), which is required for formation of a normal polar septum during sporulation;

Date:

2024-02-09

GspE/PluE family protein containing a GAF domain, with similarity to type II secretion system protein E, an essential component of type II systems involved in the export of proteins

Date:

2024-02-09

DNA recombination protein RmuC has been suggested to limit inversions at short-inverted repeats; it contains an Mg(2+)-dependent PD-(D/E)XK nuclease domain and may specifically cleave DNA structures associated with the recombination of short-inverted repeats

Date:

2024-02-09

DNA recombination protein RmuC may limit inversions at short-inverted repeats; it contains an Mg(2+)-dependent PD-(D/E)XK nuclease domain and may specifically cleave DNA structures associated with the recombination of short-inverted repeats

Date:

2024-02-09

spore coat protein CotJB is encoded by a sigma E-controlled operon that affects the composition of spore coats

Date:

2024-02-09

photosystem I (PSI) protein PsaX is a component of the cyanobacterial PSI reaction center that is composed of one copy each of PsaA, B, C, D, E, F, I, J, K, L, M and X

Date:

2024-02-09

ribonuclease E inhibitor RraB globally modulates RNA abundance by binding to RNase E and regulating its endonucleolytic activity in a substrate-dependent manner

Date:

2024-02-09

DNA recombination protein RmuC has been suggested to limit inversions at short-inverted repeats; it contains an Mg(2+)-dependent PD-(D/E)XK nuclease domain and may specifically cleave DNA structures associated with the recombination of short-inverted repeats

Date:

2024-02-09

GspE/PluE family protein similar to type II secretion system protein E, an essential component of type II systems

Date:

2024-02-09

kinesin family protein which contains an ATPase-containing motor domain found in kinesins that provides the driving force in kinesin-mediated processes; similar to silkworm kinesin-7 found in posterior silkgland (PSG) cells and may be involved in intracellular transport in these specialized secretory cells, and to the motor domain found in human kinetochore protein CENP-E

Date:

2024-02-09

M14 family zinc carboxypeptidase N/E relies on its substrate specificity and subcellular compartmentalization to prevent inappropriate cleavages that would otherwise damage the cell; it contains an extra C-terminal domain which may assist in folding of the carboxypeptidase domain, regulate enzyme activity, or be involved in interactions with other proteins or with membranes; also contains C-terminal collagen triple helix repeat domain

Date:

2024-02-09