Protein Family Models

PCI (proteasome-COP9/CSN-initiation factor) domain-containing protein is a component of multiprotein complexes; similar to Homo sapiens eukaryotic translation initiation factor 3 subunit M, Saccharomyces cerevisiae Cop9 signalosome complex subunit 11, and Gallus gallus 26S proteasome non-ATPase regulatory subunit 13

Date:

2024-02-09

PCI (proteasome-COP9/CSN-initiation factor) domain-containing protein is a component of multiprotein complexes; similar to Homo sapiens eukaryotic translation initiation factor 3 subunit M, Saccharomyces cerevisiae Cop9 signalosome complex subunit 11, and Gallus gallus 26S proteasome non-ATPase regulatory subunit 13

Date:

2024-02-09

LPXTG cell wall anchor domain-containing protein similar to Streptococcus pyogenes IgA receptor and M protein, serotype 49

Date:

2024-02-09

LPXTG cell wall anchor domain-containing protein similar to Streptococcus pyogenes IgA receptor and M protein, serotype 49

Date:

2024-02-09

LPXTG cell wall anchor domain-containing protein similar to Streptococcus pyogenes IgA receptor and M protein, serotype 49

Date:

2024-02-09

trimethylguanosine synthase catalyzes the two serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure

Date:

2024-02-09

photosystem I (PSI) protein PsaX is a component of the cyanobacterial PSI reaction center that is composed of one copy each of PsaA, B, C, D, E, F, I, J, K, L, M and X

Date:

2024-02-09

NAD(P)H-quinone oxidoreductase subunit M is a component of NDH-1, which shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain

Date:

2024-02-09

anti-sigma factor similar to Bacillus subtilis probable anti-sigma-M factor YhdL that negatively regulates sigma-M and is co-transcribed with sigma-M and yhdK

Date:

2024-02-09

NADH-quinone oxidoreductase subunit M is a component of the NADH dehydrogenase I complex, which shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain

Date:

2024-02-09

class I SAM-dependent DNA methyltransferase catalyzes the methylation of a specific DNA substrate using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor similar to type I restriction-modification system modification (M) subunit (HsdM), which together with specificity (S) subunit (HsdS), forms a methyltransferase that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence

Date:

2024-02-09

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein similar to Drosophila melanogaster zinc finger protein chinmo, longitudinals lacking protein, isoforms H/M/V, and Broad-complex core protein isoforms 1/2/3/4/5

Date:

2024-02-09

LPXTG cell wall anchor domain-containing protein similar to Streptococcus pyogenes IgA receptor and M protein, serotype 49

Date:

2024-02-09

Date:

2024-08-14

This domain represents the polycystin domain from group II of Transient receptor potential (TRP) channels (TRPP) including PKD1, PKD2, PKD2L and mucolipins. The polycystin domain display a sandwich-like shape with five beta-sheets in the tilted middle layer, three alpha-helices on one side and a large loop with two short antiparallel beta-sheets on the other [3]. [1]. 10517637. Polycystin-L is a calcium-regulated cation channel permeable to. calcium ions.. Chen XZ, Vassilev PM, Basora N, Peng JB, Nomura H, Segal Y,. Brown EM, Reeders ST, Hediger MA, Zhou J;. Nature 1999;401:383-386.. [2]. 11264013. Polycystin-2 is a novel cation channel implicated in defective. intracellular Ca(2+) homeostasis in polycystic kidney disease.. Vassilev PM, Guo L, Chen XZ, Segal Y, Peng JB, Basora N,. Babakhanlou H, Cruger G, Kanazirska M, Ye Cp, Brown EM, Hediger. MA, Zhou J;. Biochem Biophys Res Commun 2001;282:341-350.. [3]. 29567962. Cryo-EM structure of the polycystic kidney disease-like channel. PKD2L1.. Su Q, Hu F, Liu Y, Ge X, Mei C, Yu S, Shen A, Zhou Q, Yan C, Lei. J, Zhang Y, Liu X, Wang T;. Nat Commun. 2018;9:1192. (from Pfam)

Date:

2024-08-14

This is the C-terminal domain of Tab2 from plant and cyanobacteria. Tab2 was first identified in Chlamydomonas reinhardtii as a RNA binding protein required for translation of the chloroplast PsaB photosystem I subunit [1]. Later, the Tab2 homologue from Arabidopsis (Atab2) was found involved in the signalling pathway of light-controlled synthesis of photosystem proteins during early plant development, presumably functioning as an activator of translation with targets at PSI and PSII [2,3]. Directed mutagenesis experiments carried out in Chlamydomonas reinhardtii, Tab2 Swiss:Q7X8Y6, indicated the importance of a highly conserved C-terminal tripeptide WLL for normal psaB translation [1]. [1]. 14633996. Tab2 is a novel conserved RNA binding protein required for. translation of the chloroplast psaB mRNA.. Dauvillee D, Stampacchia O, Girard-Bascou J, Rochaix JD;. EMBO J. 2003;22:6378-6388.. [2]. 25725436. Large-scale genetic analysis of chloroplast biogenesis in maize.. Belcher S, Williams-Carrier R, Stiffler N, Barkan A;. Biochim Biophys Acta. 2015;1847:1004-1016.. [3]. 17139246. ATAB2 is a novel factor in the signalling pathway of. light-controlled synthesis of photosystem proteins.. Barneche F, Winter V, Crevecoeur M, Rochaix JD;. EMBO J. 2006;25:5907-5918. (from Pfam)

Date:

2024-08-14

Glycoprotein E (gE) of Alphaherpesvirus forms a complex with glycoprotein I (gI) (Pfam:PF01688), functioning as an immunoglobulin G (IgG) Fc binding protein. gE is involved in virus spread but is not essential for propagation [1]. This entry represents the N-terminal domain of gE, which interacts with gI [2,3]. [1]. 10881679. Epitopes on glycoprotein E and on the glycoprotein. E/glycoprotein I complex of bovine herpesvirus 1 are expressed. by all of 222 isolates and 11 vaccine strains.. Rijsewijk FA, Kaashoek MJ, Langeveld JP, Maris-Veldhuis MA,. Magdalena J, Verschuren SB, Meloen RH, van Oirschot JT;. Arch Virol 2000;145:921-936.. [2]. 16646632. Crystal structure of the HSV-1 Fc receptor bound to Fc reveals a. mechanism for antibody bipolar bridging.. Sprague ER, Wang C, Baker D, Bjorkman PJ;. PLoS Biol. 2006;4:e148.. [3]. 11689673. An N-terminal domain of herpes simplex virus type Ig E is. capable of forming stable complexes with gI.. Rizvi SM, Raghavan M;. J Virol. 2001;75:11897-11901. (from Pfam)

Date:

2024-08-14

This domain is found towards the C-terminal the U3 small nucleolar RNA-associated protein 20 (UTP20) from yeast and its human homologue, also known as DRIM (Down-Regulated In Metastasis). DRIM is differentially expressed in metastatic and non-metastatic human breast carcinoma cells [1]. Proteins of this entry are involved in processing of non-coding RNA as components of the small-subunit (SSU) processome; SSU processome is involved in the biogenesis of the 18S rRNA [2,3]. UTP20 is a huge alpha-solenoid that functions as a scaffold [4,5]. [1]. 9673349. Differential gene expression in mammary carcinoma cell lines:. identification of DRIM, a new gene down-regulated in metastasis.. Schwirzke M, Gnirke A, Bork P, Tarin D, Weidle UH;. Anticancer Res 1998;18:1409-1421.. [2]. 12837249. A panoramic view of yeast noncoding RNA processing.. Peng WT, Robinson MD, Mnaimneh S, Krogan NJ, Cagney G, Morris Q,. Davierwala AP, Grigull J, Yang X, Zhang W, Mitsakakis N, Ryan. OW, Datta N, Jojic V, Pal C, Canadien V, Richards D, Beattie B,. Wu LF, Altschuler SJ, Roweis S, Frey BJ, Emili A, Greenblatt JF,. Cell 2003;113:919-933.. [3]. 17498821. Human 1A6/DRIM, the homolog of yeast Utp20, functions in the 18S. rRNA processing.. Wang Y, Liu J, Zhao H, Lu W, Zhao J, Yang L, Li N, Du X, Ke Y;. Biochim Biophys Acta. 2007;1773:863-868.. [4]. 31378463. Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order. of Co-transcriptional 18S rRNA Subdomain Integration.. Cheng J, Bassler J, Fischer P, Lau B, Kellner N, Kunze R,. Griesel S, Kallas M, Berninghausen O, Strauss D, Beckmann R,. Hurt E;. Mol Cell. 2019;75:1256-1269.. [5]. 32943522. Cryo-EM . TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-08-14

Highly variable central region of the vWA-MoxR associated protein (VMAP) of the classical ternary system (vWA-MoxR-VMAP) in NTP-dependent conflict systems. VMAP-Ms may be involved in sensing of invasive entities. [1]. 32101166. Highly regulated, diversifying NTP-dependent biological conflict. systems with implications for the emergence of multicellularity.. Kaur G, Burroughs AM, Iyer LM, Aravind L;. Elife. 2020; [Epub ahead of print] (from Pfam)

Date:

2024-08-14

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001740) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide, in particular the phthoxazolin biosynthetic gene cluster from Streptomyces avermitilis [1]. [1]. 29324854. Characterization of the biosynthetic gene cluster for cryptic. phthoxazolin A in Streptomyces avermitilis.. Suroto DA, Kitani S, Arai M, Ikeda H, Nihira T;. PLoS One. 2018;13:e0190973. (from Pfam)

Date:

2024-08-14