Protein Family Models

This version of the C2 domain was initally identified in the vertebrate estrogen early-induced gene 1 (EEIG1) [1], and its Drosophila ortholog required for uptake of dsRNA via the endocytotic machinery to induce RNAi silencing [2]. It is also in C.elegans ortholog Sym-3 (SYnthetic lethal with Mec-3) and the mammalian protein EHBP1 (EH domain Binding Protein-1) that regulates endocytotic recycling and two plant proteins, RPG that regulates Rhizobium-directed polar growth and PMI1 (Plastid Movement Impaired 1) that is essential for intracellular movement of chloroplasts in response to blue light [2]. [1]. 14605097. Identification of estrogen-responsive genes by complementary. deoxyribonucleic acid microarray and characterization of a novel. early estrogen-induced gene: EEIG1.. Wang DY, Fulthorpe R, Liss SN, Edwards EA;. Mol Endocrinol. 2004;18:402-411.. [2]. 20713135. Identification of novel families and classification of the C2. domain superfamily elucidate the origin and evolution of. membrane targeting activities in eukaryotes.. Zhang D, Aravind L;. Gene. 2010;469:18-30. (from Pfam)

Date:

2024-08-14