APT1 - Protein Family Models

Select item 4223541.

This is the C-terminal region of the Hobbit family of proteins, which includes Hobbit from Drosophila and its homologues such as human BLTP2, FMP27 from yeast, maize protein APT1 and Arabidopsis homologues SABRE and KIP [2,3]. These proteins are localised to endoplasmic reticulum-plasma membrane (ER-PM) contact sites described as conserved lipid-binding proteins. They long hydrophobic groove and can mediate bulk transport of lipids between organelles. These proteins belong to the repeating beta-groove superfamily whose members share the same structure consisting of multiple repeating modules consisting of five beta-sheets followed by a loop [2-4]. [1]. 16299389. The maize aberrant pollen transmission 1 gene is a SABRE/KIP. homolog required for pollen tube growth.. Xu Z, Dooner HK;. Genetics. 2006;172:1251-1261.. [2]. 34415038. The Hob proteins are novel and conserved lipid-binding proteins. at ER-PM contact sites.. Neuman SD, Jorgensen JR, Cavanagh AT, Smyth JT, Selegue JE, Emr. SD, Bashirullah A;. J Cell Sci. 2022; [Epub ahead of print]. [3]. 35491307. A novel superfamily of bridge-like lipid transfer proteins.. Neuman SD, Levine TP, Bashirullah A;. Trends Cell Biol. 2022;32:962-974.. [4]. 35015055. Vps13-like proteins provide phosphatidylethanolamine for GPI. anchor synthesis in the ER.. Toulmay A, Whittle FB, Yang J, Bai X, Diarra J, Banerjee S,. Levine TP, Golden A, Prinz WA;. J Cell Biol. 2022; [Epub ahead of print] (from Pfam)

Date:: 2024-08-14

Family Accession:: NF021839.5
Method:: HMM

Select item 4198962.

Fmp27/BLTP2/Hobbit, GFWDK motif-containg RBG unit

This entry includes Hobbit protein from Drosophila melanogaster and its homologues such as Bridge-like lipid transfer protein family 2 member ((BLTP2/KIAA0100) from human and FMP27 from yeast, referred to as Hob proteins [1-3]. They are localised to endoplasmic reticulum-plasma membrane (ER-PM) contact sites described as conserved lipid-binding proteins. They have a long hydrophobic groove and can mediate bulk transport of lipid between organelles. This entry also includes maize protein APT1 and Arabidopsis homologues SABRE and KIP [2]. Members of this entry belong to the RBG superfamily which all share the same structure consisting of multiple repeating modules consisting of five beta-sheets followed by a loop. This entry represents a RBG module with a conserved GFWDK sequence motif. [1]. 15314641. Gene loops juxtapose promoters and terminators in yeast.. O'Sullivan JM, Tan-Wong SM, Morillon A, Lee B, Coles J, Mellor. J, Proudfoot NJ;. Nat Genet. 2004;36:1014-1018.. [2]. 35491307. A novel superfamily of bridge-like lipid transfer proteins.. Neuman SD, Levine TP, Bashirullah A;. Trends Cell Biol. 2022;32:962-974.. [3]. 35015055. Vps13-like proteins provide phosphatidylethanolamine for GPI. anchor synthesis in the ER.. Toulmay A, Whittle FB, Yang J, Bai X, Diarra J, Banerjee S,. Levine TP, Golden A, Prinz WA;. J Cell Biol. 2022; [Epub ahead of print]. [4]. 34415038. The Hob proteins are novel and conserved lipid-binding proteins. at ER-PM contact sites.. Neuman SD, Jorgensen JR, Cavanagh AT, Smyth JT, Selegue JE, Emr. SD, Bashirullah A;. J Cell Sci. 2022; [Epub ahead of print] (from Pfam)