Protein Family Models

FAD-binding oxidoreductase catalyzes the oxidation or reduction of a specific substrate using flavin adenine dinucleotide (FAD) as a cofactor

Date:

2023-12-19

NAD(P)/FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant, similar to Homo sapiens ferroptosis suppressor protein and Saccharomyces cerevisiae apoptosis-inducing factor

Date:

2023-12-19

The PPOX family (see PF01243) contains pyridoxamine 5'-phosphate oxidase and other enzymes of various (mostly unknown) function, most using FMN but some using F420 as a cofactor. The uncharacterized narrow subfamily described here is widespread in Cyanobacteria, and is named for Npun_F5749 from Nostoc punctiforme PCC 73102. Encoding species typically lack the capability to synthesize F420, so most likely all members bind FMN rather than F420. Npun_F5749 has a solved crystal structure (PDB:2I51) with bound FMN. This model has been revised, with a narrower seed and higher cutoffs, and is now equivalog-level. Related plant proteins, now outside the scope of this model, include AT2G46580 from Arabidopsis, shown to have weak pyridoxamine 5'-phosphate oxidase activity.

Date:

2023-11-15

heme oxygenase-like domain-containing protein such as pyrroloquinoline-quinone synthase that catalyzes the ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ

Date:

2023-10-27

molybdopterin-dependent oxidoreductase family protein containing molybdopterin-binding and MopB_CT domains

Date:

2023-10-27

xanthine dehydrogenase family similar to Homo sapiens xanthine dehydrogenase/oxidase which catalyzes the oxidation of hypoxanthine to xanthine, as well as the oxidation of xanthine to uric acid

Date:

2023-09-25

NAD(P)/FAD-dependent oxidoreductase similar to flavin-dependent halogenases that mediate the halogenation (e.g. chlorination) of substrates

Date:

2023-09-18

SDR (short-chain dehydrogenases/reductases) family oxidoreductase similar to NADP(+)-dependent alcohol dehydrogenase from Ralstonia sp. (RasDH); classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue

Date:

2023-09-01

NAD(P)/FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; similar to nitrite reductase large subunit NirB

Date:

2023-08-31

saccharopine dehydrogenase family protein similar to Geobacillus stearothermophilus lysine 6-dehydrogenase that catalyzes the oxidative deamination of L-lysine in the presence of NAD

Date:

2023-08-29

copper resistance system multicopper oxidase similar to Escherichia coli copper resistance protein A, which is required for the copper-inducible expression of copper resistance and may have oxidase activity

Date:

2023-06-04

FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant

Date:

2022-12-12

FAD-dependent monooxygenase such as 6-hydroxynicotinate 3-monooxygenase, which catalyzes the decarboxylative hydroxylation of 6-hydroxynicotinic acid (6-HNA) to 2,5-dihydroxypyridine (2,5-DHP) with concomitant oxidation of NADH, a step in the aerobic nicotinate degradation pathway

Date:

2022-11-09

FdhF/YdeP family oxidoreductase belongs to the molybdopterin-binding (MopB) superfamily of proteins

Date:

2022-09-13

oxidoreductase similar to Escherichia coli putative oxidoreductase YdgJ

Date:

2022-10-26

NAD(P)/FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; similar to the antibiotic lankacidin LkcE from Streptomyces rochei, which catalyzes both an unusual amide oxidation, and a subsequent intramolecular Mannich reaction to form the polyketide macrocycle

Date:

2022-11-01

NAD(P)/FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant

Date:

2022-08-10

gluconate 2-dehydrogenase subunit 3 family protein similar to Erwinia cypripedii gluconate 2-dehydrogenase subunit 3, also called the small subunit, which is part of the heterotrimer that catalyzes the conversion of D-gluconate to 2-dehydro-D-gluconate

Date:

2022-09-02

oxygenase MpaB family protein similar to Penicillium ER-bound oxygenase mpaB/mpaB', which is part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), and Streptomyces rubber oxygenase

Date:

2022-09-06

cytochrome P450 catalyzes the oxidation of organic species by molecular oxygen, by the oxidative addition of atomic oxygen into an unactivated C-H or C-C bond

Date:

2022-01-28