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Study Description
Through clinical trials focused on molecularly guided therapy in pediatric cancers (NCT01355679, NCT01802567, NCT02162732), the Beat Childhood Cancer Consortium performed paired tumor/normal whole exome sequencing and/or tumor mRNA sequencing for 202 pediatric or adolescent young adult patients with rare, relapsed and refractory cancers (including neuroblastoma, Ewing sarcoma, osteosarcoma, rhabdomyosarcoma, ependymoma, glioma, and other rare solid tumors). A subset of these patients had multiple biopsies sequenced, including longitudinal profiling.
  • Study Design:
    • Tumor vs. Matched-Normal
  • Study Type:
    • Cohort
    • Exome Sequencing
    • Transcriptome Sequencing
    • Tumor vs. Matched-Normal
  • Total number of consented subjects: 202
  • Subject Sample Telemetry Report (SSTR)
Authorized Access
Publicly Available Data
  Link to other NCBI resources related to this study
Selected Publications
Diseases/Traits Related to Study (MeSH terms)
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Study Attribution
  • Principal Investigator
    • Jeffrey M. Trent. Translational Genomics Research Institute (TGen), Phoenix, Arizona, USA.
    • Giselle L. Saulnier Sholler. Levine Children's Hospital, Charlotte, North Carolina, USA.