GWAS for Membranous Nephropathy

Primary membranous nephropathy (MN) is a rare autoimmune cause of kidney failure. This dataset is from a genome-wide association study (GWAS) designed to identify novel genetic risk loci for MN. The provided cohort (named as European-1 Cohort) is composed of 611 cases of primary MN and 1,246 healthy controls of European ancestry. This cohort was used in the GWAS meta-analysis, as described in the manuscript entitled "Genetic architecture of membranous nephropathy and its potential diagnostic implications" (Nature Communications 2020, in press).

The genome-wide summary statistics, including trans-ethnic meta-analysis across 8 GWAS cohorts of European and East Asian ancestry and ethnicity specific meta-analyses, are freely available for download on the Kiryluk lab website: http://www.columbiamedicine.org/divisions/kiryluk/resources.php.

• Study Design:
  • Case-Control
• Study Type:
  • Case-Control
  • Cohort
• dbGaP estimated ancestry using GRAF-pop
• Total number of consented subjects: 1857
• Subject Sample Telemetry Report (SSTR)

• BioProject
• PubMed
• MeSH
• PMC

All cases used in this study were defined by a kidney biopsy diagnosis of idiopathic MN and any suspected secondary cases due to drugs, malignancy, infection, or autoimmune disease were excluded. All controls used for discovery involved healthy population controls and any individuals with a known diagnosis of kidney disease were excluded. All cases and controls are of genetically-defined European ancestry.

• Primary Phenotype: Glomerulonephritis, Membranous

• Principal Investigator
  • Krzysztof Kiryluk, MD. Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.