Women's Health Initiative (WHI)

This study phs001077 WHI Colorectal Cancer contains genotype and phenotype of subjects available from the phs001077 study. Summary level phenotypes for the NCI GECCO Consortium study participants can be viewed at the top-level study page phs001078 GECCO Consortium. Individual level phenotype data and molecular data for all GECCO Consortium top-level study and individual studies are available by requesting Authorized Access to the NCI GECCO Consortium phs001078 study.

This study was included as part of a GWAS consortium. The Women's Health Initiative (WHI) comprises a Clinical Trial (CT) arm, an Observational Study (OS) arm, and several extension studies, and through 40 clinical centers across the U.S. WHI recruited 161,808 post-menopausal women aged 50 to 79 years. WHI samples genotyped were identified utilizing the WHI August 2009 database. Cases were comprised of centrally adjudicated colon and colorectal cancer cases from the OS and CT who were not previously genotyped. A subset of cases and controls were selected for genotyping for this project.

• Study Weblinks:
  • Women's Health Iniative
• Study Design:
  • Case-Control
• Study Type:
  • Case-Control
  • Longitudinal
• Total number of consented subjects: 2191
• Subject Sample Telemetry Report (SSTR)

• BioProject
• PubMed
• BioSample
• MeSH
• PMC

Eligibility criteria for cases included:

• Post-menopausal women
• Aged 50 to 79 years
• First primary colorectal cancer diagnosis
• Available DNA
• Self-reported White
• Appropriate consent for data submission into dbGaP

Colorectal cancer cases exclusions:

• A prior history of colorectal cancer at baseline
• Colorectal cancer before baseline
• In situ cases
• Neuroendocrine carcinoma (large cell)
• Squamous cell carcinoma
• Carcinoid tumor
• Goblet cell carcinoid
• Any type of lymphoma, including non-Hodgkin, Mantle cell, large B-cell, or follicular lymphoma

Controls were matched on age (within years), race/ethnicity, WHI date (within three years), WHI Calcium and Vitamin D study date (within three years), and randomization arms (OS flag, hormone therapy assignments, dietary modification assignments, calcium/vitamin D assignments). In addition, they were matched on the four regions of randomization centers. Controls with a prior history of colorectal cancer at baseline were excluded.

• Primary Phenotype: Colorectal Neoplasms

• WHI Principal Investigator
  • Garnet Anderson, PhD. Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
• WHI Funding Source
  • HHSN268201600018C. Fred Hutch. National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • HHSN268201600003C. Stanford University. National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USAA.
  • HHSN268201600002C. The Ohio State University. National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • HHSN268201100004C. Wake Forest University. National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • HHSN268201600001C. University at Buffalo. National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.