Jump to: | Authorized Access | | | Attribution | | | Authorized Requests |
- Study Description
-
Important Links and Information
-
Request access via Authorized Access
- Instructions for requestors
- Data Use Certification (DUC) Agreement
- Talking Glossary of Genetic Terms
The Chronic Renal Insufficiency Cohort (CRIC study) was established in 2001 by the National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK) to improve the understanding of the relationship between chronic kidney disease and cardiovascular disease. The goals of the CRIC Study are to examine risk factors for progression of chronic kidney disease and cardiovascular disease among patients with chronic kidney disease and to develop predictive models to identify high-risk subgroups, informing future treatment trials and increasing application of available preventive therapies.
- Study Weblinks:
- Study Design:
- Case Set
- Study Type:
- Cohort
- dbGaP estimated ancestry using GRAF-pop
- Total number of consented subjects: 3598
- Subject Sample Telemetry Report (SSTR)
-
Request access via Authorized Access
- Authorized Access
- Publicly Available Data
- Link to other NCBI resources related to this study
- Study Inclusion/Exclusion Criteria
Participants are no longer being enrolled in the study. The following Inclusion/Exclusion Criteria were followed at the time of participant recruitment.
Inclusion: 21 to 74 years; Age Based eGFR: 21-44 years 20-70 ml/min/1/73m2), 45-64 years 20-60 ml/min/1/73m2, 65-74 years 20-50 ml/min/1/73m2.
Exclusion: Institutionalized, unable or unwilling to provide informed consent, participant appears unlikely or unable to participate in the required study procedures as assessed by the investigator, study coordinator or designee, NYHA Class III or IV heart failure at baseline, known cirrhosis based on patient self-report, known HIV infection and/or AIDS based on patient self-report, present participation in the AASK Cohort Study, pregnant women.
- Molecular Data
-
Type Source Platform Number of Oligos/SNPs SNP Batch Id Comment Whole Genome Genotyping Illumina HumanOmni1-Quad_v1-0_B 1051295 1049033 - Study History
2001: design of the study began
2004-2008: recruitment of participants conducted resulting in over 3000 enrolled participants
2008: study funding extended for 5 years
2008: phase 2 of the study began
2012: application for phase 3 funding in development- Selected Publications
- Diseases/Traits Related to Study (MeSH terms)
-
- Primary Phenotype: Chronic Renal Insufficiency
- Authorized Data Access Requests
-
See articles in PMC citing this study accession
- Study Attribution
-
-
Principal Investigator, Scientific and Data Coordinating Center, CRIC Steering Committee Chair
- Harold I. Feldman, MD, MSCE. University of Pennsylvania, Philadelphia, PA, USA.
-
Principal Investigators, Clinical Center
- Raymond R. Townsend, MD. University of Pennsylvania, Philadelphia, PA, USA.
- Lawrence J. Appel, MD, MPH. The Johns Hopkins University, Baltimore, MD, USA.
- Mahboob Rahman, MD. University Hospitals of Cleveland, Cleveland, OH, USA.
- Akinlolu Ojo, MD, PhD. University of Michigan at Ann Arbor, Ann Arbor, MI, USA.
- James P. Lash, MD. University of Illinois, Chicago, IL, USA.
- Jiang He, MD, PhD. Tulane University, New Orleans, LA, USA.
- Alan S. Go, MD. Kaiser Permanente, Oakland, CA, USA.
-
Project Officer, NIDDK
- John W. Kusek, PhD. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
-
Principal Investigator, Scientific and Data Coordinating Center, CRIC Steering Committee Chair