Jump to: | Authorized Access | | | Attribution | | | Authorized Requests |
- Study Description
-
Important Links and Information
-
Request access via Authorized Access
- Instructions for requestors
- Data Use Certification (DUC) Agreement
- Talking Glossary of Genetic Terms
Schizophrenia is characterized by high heritability (~80%), yet the identification of susceptibility genes has proven extremely challenging. The Ashkenazi Jewish population, derived from a limited number of founders, may be enriched for a subset of susceptibility alleles, which may also have higher odds ratios than those detected by previous studies. GWAS was conducted in a large Ashkenazi case-control cohort, derived from the Hebrew University Genetic Resource, using the Illumina HumanOmni1-Quad BeadChip.
- Study Design:
- Case-Control
- Study Type:
- Case-Control
- dbGaP estimated ancestry using GRAF-pop
- Total number of consented subjects: 3096
- Subject Sample Telemetry Report (SSTR)
-
Request access via Authorized Access
- Authorized Access
- Publicly Available Data
- Link to other NCBI resources related to this study
- Study Inclusion/Exclusion Criteria
Inclusion criteria for all subjects: self-identified 4 grandparents of Ashkenazi Jewish heritage Inclusion criteria for cases: hospitalized inpatients meeting DSM-IV criteria for schizophrenia or schizoaffective disorder.
- Molecular Data
-
Type Source Platform Number of Oligos/SNPs SNP Batch Id Comment Whole Genome Genotyping Illumina HumanOmni1-Quad_v1-0_B 1051295 1049033 - Study History
Inclusion criteria for all subjects: self-identified 4 grandparents of Ashkenazi Jewish heritage Inclusion criteria for cases: hospitalized inpatients meeting DSM-IV criteria for schizophrenia or schizoaffective disorder.
Exclusion criteria for cases: subjects diagnosed with at least one of the following disorders: psychotic disorder due to a general medical condition, substance-induced psychotic disorder, or any Cluster A (schizotypal, schizoid, or paranoid) personality disorder. Exclusion criteria for controls: report of any chronic disease or taking any medication at the time of blood draw.
- Selected Publications
- Diseases/Traits Related to Study (MeSH terms)
-
- Primary Phenotype: Schizophrenia
- Authorized Data Access Requests
- Study Attribution
-
-
Principal Investigator
- Todd Lencz, PhD. Feinstein Institute for Medical Research, North Shore - LIJ Health System, Manhasset, NY, USA.
-
Funding Source
- RC2MH089964. National Institutes of Health, Bethesda, MD, USA.
-
Principal Investigator