Genetics of Schizophrenia in an Ashkenazi Jewish Case-Control Cohort

Schizophrenia is characterized by high heritability (~80%), yet the identification of susceptibility genes has proven extremely challenging. The Ashkenazi Jewish population, derived from a limited number of founders, may be enriched for a subset of susceptibility alleles, which may also have higher odds ratios than those detected by previous studies. GWAS was conducted in a large Ashkenazi case-control cohort, derived from the Hebrew University Genetic Resource, using the Illumina HumanOmni1-Quad BeadChip.

• Study Design:
  • Case-Control
• Study Type:
  • Case-Control
• dbGaP estimated ancestry using GRAF-pop
• Total number of consented subjects: 3096
• Subject Sample Telemetry Report (SSTR)

• BioProject
• BioSample
• MeSH

Inclusion criteria for all subjects: self-identified 4 grandparents of Ashkenazi Jewish heritage Inclusion criteria for cases: hospitalized inpatients meeting DSM-IV criteria for schizophrenia or schizoaffective disorder.

Inclusion criteria for all subjects: self-identified 4 grandparents of Ashkenazi Jewish heritage Inclusion criteria for cases: hospitalized inpatients meeting DSM-IV criteria for schizophrenia or schizoaffective disorder.

Exclusion criteria for cases: subjects diagnosed with at least one of the following disorders: psychotic disorder due to a general medical condition, substance-induced psychotic disorder, or any Cluster A (schizotypal, schizoid, or paranoid) personality disorder. Exclusion criteria for controls: report of any chronic disease or taking any medication at the time of blood draw.

• Primary Phenotype: Schizophrenia

• Principal Investigator
  • Todd Lencz, PhD. Feinstein Institute for Medical Research, North Shore - LIJ Health System, Manhasset, NY, USA.
• Funding Source
  • RC2MH089964. National Institutes of Health, Bethesda, MD, USA.