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- Study Description
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Important Links and Information
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- Instructions for requestors
- Data Use Certification (DUC) Agreement
- Talking Glossary of Genetic Terms
We have conducted genetic studies of disease-associated quantitative phenotypes, including microbiome and gene expression studies, by genotyping and/or sequencing in the Hutterites, a founder population of European descent. The Hutterites who have participated in our studies live on communal farms in South Dakota and are related to each other through multiple lines of descent in a 3,657-person, 13-generation pedigree with 64 founders. The small number of founding genomes reduces genetic heterogeneity whereas their communal lifestyle ensures that non-genetic factors are remarkably uniform between individuals. Our sample includes >1,600 subjects who have participated in our studies of fertility (since 1982), asthma, cardiovascular disease and other complex phenotypes (since 1993), microbiome studies (since 2011), and/or immune response (since 2012).
- Study Design:
- Prospective Longitudinal Cohort
- Study Type:
- Population
- Cross-Sectional
- Longitudinal
- dbGaP estimated ancestry using GRAF-pop
- Total number of consented subjects: 365
- Subject Sample Telemetry Report (SSTR)
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- Authorized Access
- Publicly Available Data
- Link to other NCBI resources related to this study
- Study Inclusion/Exclusion Criteria
Individuals living in the Hutterite colonies that we visited who were age 6 years and older (for some studies 15 years and older) were invited to participate in our studies of complex phenotypes and the gut and nasal microbiome; see descriptions of individual studies for details on study-specific inclusion/exclusion criteria.
- Molecular Data
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Type Source Platform Number of Oligos/SNPs SNP Batch Id Comment Whole Genome Genotyping Affymetrix Mapping250K_Nsp 262264 33767 Affymetrix 500K Set comprises Mapping250K_Nsp and Mapping250K_Sty Arrays Whole Genome Genotyping Affymetrix Mapping250K_Sty 238304 33766 Affymetrix 500K Set comprises Mapping250K_Nsp and Mapping250K_Sty Arrays Whole Genome Genotyping Affymetrix GenomeWideSNP_5 440792 1049350 Whole Genome Genotyping Affymetrix AFFY_6.0 934940 52074 Targeted Region Genotyping Illumina nsSNP Custom Array 1536 N/A Custom array for non-synonymous SNPs (genome-wide)
Custom array for non-synonymous SNPs (genome-wide)16S rRNA Sequencing Illumina HiSeq 2000 N/A N/A V4 region of the 16S gene; PMID: 24618913; n=139 || version 3; V4 region of 16S; PMID: 28143570; n=144 RNA Sequencing Illumina HiSeq 2000 N/A N/A PMID: 26931462, bioRxiv: 150185, bioRxiv: 344457 || PMID: 29977032; n=103 || PMID: 29737278; n=45 Whole Genome Sequencing Illumina HiSeq 2000 N/A N/A PMID: 23001126; n=16 Whole Genome Sequencing Complete Genomics Assembler Version 2.0.2.20; File Format 2.0 N/A N/A PMID: 25735005; n=98 - Study History
Our sample includes >1600 subjects who participated in our genetic studies beginning in 1982.
- Selected Publications
- Diseases/Traits Related to Study (MeSH terms)
- Authorized Data Access Requests
- Study Attribution
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Principal Investigator
- Carole Ober, PhD. University of Chicago, Chicago, IL, USA.
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Institute
- University of Chicago, Chicago, IL, USA.
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Funding Sources
- R01HL085197. National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
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Principal Investigator