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Select item 70045331.

Epidermal growth factor receptor mRNA expression: A potential molecular escape mechanism from regorafenib

Satoshi Matsusaka, Diana L. Hanna, Yan Ning, Dongyun Yang, Shu Cao, Martin D. Berger, Yuji Miyamoto, Mitsukuni Suenaga, Shingo Dan, Tetsuo Mashima, Hiroyuki Seimiya, Wu Zhang, Heinz‐Josef Lenz

Cancer Sci. 2020 Feb; 111(2): 441–450. Published online 2020 Jan 27. doi: 10.1111/cas.14273

PMCID:: PMC7004533

Abstract Article PDF–392K

Select item 1462042.

A 1.8 kb alternative transcript from the human epidermal growth factor receptor gene encodes a truncated form of the receptor.

J L Reiter, N J Maihle

Nucleic Acids Res. 1996 Oct 15; 24(20): 4050–4056. doi: 10.1093/nar/24.20.4050

PMCID:: PMC146204

Summary PDF–178K

Select item 69665293.

Standardization of Somatic Variant Classifications in Solid and Haematological Tumours by a Two-Level Approach of Biological and Clinical Classes: An Initiative of the Belgian ComPerMed Expert Panel

Guy Froyen, Marie Le Mercier, Els Lierman, Karl Vandepoele, Friedel Nollet, Elke Boone, Joni Van der Meulen, Koen Jacobs, Suzan Lambin, Sara Vander Borght, Els Van Valckenborgh, Aline Antoniou, Aline Hébrant

Cancers (Basel) 2019 Dec; 11(12): 2030. Published online 2019 Dec 16. doi: 10.3390/cancers11122030

PMCID:: PMC6966529

Abstract Article PDF–710K

Select item 66251394.

Tumor mutational signatures in sebaceous skin lesions from individuals with Lynch syndrome

Peter Georgeson, Michael D. Walsh, Mark Clendenning, Simin Daneshvar, Bernard J. Pope, Khalid Mahmood, Jihoon E. Joo, Harindra Jayasekara, Mark A. Jenkins, Ingrid M. Winship, Daniel D. Buchanan

Mol Genet Genomic Med. 2019 Jul; 7(7): e00781. Published online 2019 Jun 4. doi: 10.1002/mgg3.781

PMCID:: PMC6625139

Abstract Article PDF–879K

Select item 61598745.

COSMIC-3D provides structural perspectives on cancer genetics for drug discovery

Harry C. Jubb, Harpreet K. Saini, Marcel L. Verdonk, Simon A. Forbes

Nat Genet. Author manuscript; available in PMC 2019 Mar 1.

Published in final edited form as: Nat Genet. 2018 Sep; 50(9): 1200–1202. doi: 10.1038/s41588-018-0214-9

PMCID:: PMC6159874

Abstract Article PDF–495K

Select item 61577926.

Label-free real-time ultrasensitive monitoring of non-small cell lung cancer cell interaction with drugs

Hailang Dai, Yihang Jiao, Zhangchi Sun, Zhuangqi Cao, Xianfeng Chen

Biomed Opt Express. 2018 Sep 1; 9(9): 4149–4161. Published online 2018 Aug 7. doi: 10.1364/BOE.9.004149

PMCID:: PMC6157792

Abstract Article PDF–5.1M

Select item 59866597.

Elucidation of the critical epitope of an anti-EGFR monoclonal antibody EMab-134

Mika K. Kaneko, Shinji Yamada, Shunsuke Itai, Yao-Wen Chang, Takuro Nakamura, Miyuki Yanaka, Yukinari Kato

Biochem Biophys Rep. 2018 Jul; 14: 54–57. Published online 2018 Apr 12. doi: 10.1016/j.bbrep.2018.03.010

PMCID:: PMC5986659

Abstract Article PDF–1.9M

Select item 58473438.

Redirecting T-cell specificity to EGFR using mRNA to self-limit expression of chimeric antigen receptor

Hillary G. Caruso, Hiroki Torikai, Ling Zhang, Sourindra Maiti, Jianliang Dai, Kim-Anh Do, Harjeet Singh, Helen Huls, Dean A. Lee, Richard E. Champlin, Amy B. Heimberger, Laurence J.N. Cooper

J Immunother. Author manuscript; available in PMC 2018 Mar 12.

Published in final edited form as: J Immunother. 2016 Jun; 39(5): 205–217. doi: 10.1097/CJI.0000000000000126

PMCID:: PMC5847343

Abstract Article PDF–2.8M

Select item 56069569.

Significant Improvement in Detecting BRAF, KRAS, and EGFR Mutations Using Next-Generation Sequencing as Compared with FDA-Cleared Kits

Wanlong Ma, Steven Brodie, Sally Agersborg, Vincent A. Funari, Maher Albitar

Mol Diagn Ther. 2017; 21(5): 571–579. Published online 2017 Jun 21. doi: 10.1007/s40291-017-0290-z

PMCID:: PMC5606956

Abstract Article PDF–592K

Select item 552967010.

The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion

Runqiu Jiang, Junwei Tang, Yun Chen, Lei Deng, Jie Ji, Yu Xie, Ke Wang, Wei Jia, Wen-Ming Chu, Beicheng Sun

Nat Commun. 2017; 8: 15129. Published online 2017 May 25. doi: 10.1038/ncomms15129

PMCID:: PMC5529670

Abstract Article PDF–2.8M

Select item 528285111.

Towards standardization of next-generation sequencing of FFPE samples for clinical oncology: intrinsic obstacles and possible solutions

Maxim Ivanov, Konstantin Laktionov, Valery Breder, Polina Chernenko, Ekaterina Novikova, Ekaterina Telysheva, Sergey Musienko, Ancha Baranova, Vladislav Mileyko

J Transl Med. 2017; 15: 22. Published online 2017 Jan 31. doi: 10.1186/s12967-017-1125-8

PMCID:: PMC5282851

Abstract Article PDF–1.4M

Select item 521058112.

PubChem BioAssay: 2017 update

Yanli Wang, Stephen H. Bryant, Tiejun Cheng, Jiyao Wang, Asta Gindulyte, Benjamin A. Shoemaker, Paul A. Thiessen, Siqian He, Jian Zhang

Nucleic Acids Res. 2017 Jan 4; 45(Database issue): D955–D963. Published online 2016 Nov 28. doi: 10.1093/nar/gkw1118

PMCID:: PMC5210581

Abstract Article PDF–2.8M

Select item 520400213.

Clinical Pharmacogenetic Testing and Application: Laboratory Medicine Clinical Practice Guidelines

Sollip Kim, Yeo-Min Yun, Hyo-Jin Chae, Hyun-Jung Cho, Misuk Ji, In-Suk Kim, Kyung-A Wee, Woochang Lee, Sang Hoon Song, Hye In Woo, Soo-Youn Lee, Sail Chun

Ann Lab Med. 2017 Mar; 37(2): 180–193. Published online 2016 Dec 20. doi: 10.3343/alm.2017.37.2.180

PMCID:: PMC5204002

Abstract Article PDF–299K

Select item 481670614.

Clinical Validation and Implementation of a Targeted Next-Generation Sequencing Assay to Detect Somatic Variants in Non-Small Cell Lung, Melanoma, and Gastrointestinal Malignancies

Kevin E. Fisher, Linsheng Zhang, Jason Wang, Geoffrey H. Smith, Scott Newman, Thomas M. Schneider, Rathi N. Pillai, Ragini R. Kudchadkar, Taofeek K. Owonikoko, Suresh S. Ramalingam, David H. Lawson, Keith A. Delman, Bassel F. El-Rayes, Malania M. Wilson, H. Clifford Sullivan, Annie S. Morrison, Serdar Balci, N. Volkan Adsay, Anthony A. Gal, Gabriel L. Sica, Debra F. Saxe, Karen P. Mann, Charles E. Hill, Fadlo R. Khuri, Michael R. Rossi

J Mol Diagn. 2016 Mar; 18(2): 299–315. doi: 10.1016/j.jmoldx.2015.11.006

PMCID:: PMC4816706

Abstract Article PDF–1.2M

Select item 462422815.

Tuning sensitivity of CAR to EGFR density limits recognition of normal tissue while maintaining potent anti-tumor activity

Hillary G. Caruso, Lenka V. Hurton, Amer Najjar, David Rushworth, Sonny Ang, Simon Olivares, Tiejuan Mi, Kirsten Switzer, Harjeet Singh, Helen Huls, Dean A. Lee, Amy B. Heimberger, Richard E. Champlin, Laurence J. N. Cooper

Cancer Res. Author manuscript; available in PMC 2016 Sep 1.

Published in final edited form as: Cancer Res. 2015 Sep 1; 75(17): 3505–3518. doi: 10.1158/0008-5472.CAN-15-0139

PMCID:: PMC4624228

Abstract Article PDF–1.3M

Select item 415648216.

Altered trafficking of mutated growth factor receptors and their associated molecules: implication for human cancers

Shunsuke Kon, Nobuhide Kobayashi, Masanobu Satake

Cell Logist. 2014; 4: e28461. Published online 2014 Mar 18. doi: 10.4161/cl.28461

PMCID:: PMC4156482

Abstract Article PDF–903K

Select item 386967417.

Drug Resistance Missense Mutations in Cancer Are Subject to Evolutionary Constraints

Ran Friedman

PLoS One. 2013; 8(12): e82059. Published online 2013 Dec 20. doi: 10.1371/journal.pone.0082059

PMCID:: PMC3869674

Abstract Article PDF–722K

Select item 360897518.

Detection and characterization of classical and “uncommon” exon 19 Epidermal Growth Factor Receptor mutations in lung cancer by pyrosequencing

Luisella Righi, Alessandra Cuccurullo, Simona Vatrano, Susanna Cappia, Daniela Giachino, Paolo De Giuli, Mara Ardine, Silvia Novello, Marco Volante, Giorgio V Scagliotti, Mauro Papotti

BMC Cancer. 2013; 13: 114. Published online 2013 Mar 13. doi: 10.1186/1471-2407-13-114

PMCID:: PMC3608975

Abstract Article PDF–1.1M

Select item 350726019.

Erlotinib binds both inactive and active conformations of the EGFR tyrosine kinase domain

Jin H. Park, Yingting Liu, Mark A. Lemmon, Ravi Radhakrishnan

Biochem J. 2012 Dec 15; 448(Pt 3): 417–423. Prepublished online 2012 Oct 29. Published online 2012 Nov 21. doi: 10.1042/BJ20121513

PMCID:: PMC3507260

Abstract Article PDF–1.3M

Select item 344423220.

Regulation and physiological roles of the calpain system in muscular disorders

Hiroyuki Sorimachi, Yasuko Ono

Cardiovasc Res. 2012 Oct 1; 96(1): 11–22. Published online 2012 Apr 27. doi: 10.1093/cvr/cvs157

PMCID:: PMC3444232

Abstract Article PDF–573K

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