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Items: 1 to 20 of 30

1.
De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly
Jeong Ho Lee, My Huynh, Jennifer L Silhavy, Sangwoo Kim, Tracy Dixon-Salazar, Andrew Heiberg, Eric Scott, Vineet Bafna, Kiley J Hill, Adrienne Collazo, Vincent Funari, Carsten Russ, Stacey B Gabriel, Gary W Mathern, Joseph G Gleeson
Nat Genet. Author manuscript; available in PMC 2015 May 4.
Published in final edited form as: Nat Genet. 2012 Aug; 44(8): 941–945. Published online 2012 Jun 24. doi: 10.1038/ng.2329
PMCID:
PMC4417942
AbstractArticlePDF–1.3M
2.
Somatic Activation of AKT3 Causes Hemispheric Developmental Brain Malformations
Annapurna Poduri, Gilad D. Evrony, Xuyu Cai, Princess Christina Elhosary, Rameen Beroukhim, Maria K. Lehtinen, L. Benjamin Hills, Erin L. Heinzen, Anthony Hill, R. Sean Hill, Brenda J. Barry, Blaise F.D. Bourgeois, James J. Riviello, A. James Barkovich, Peter M. Black, Keith L. Ligon, Christopher A. Walsh
Neuron. Author manuscript; available in PMC 2012 Oct 12.
Published in final edited form as: Neuron. 2012 Apr 12; 74(1): 41–48. doi: 10.1016/j.neuron.2012.03.010
PMCID:
PMC3460551
AbstractArticlePDF–2.3M
3.
De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes
Jean-Baptiste Rivière, Ghayda M. Mirzaa, Brian J. O’Roak, Margaret Beddaoui, Diana Alcantara, Robert L. Conway, Judith St-Onge, Jeremy A. Schwartzentruber, Karen W. Gripp, Sarah M. Nikkel, Thea Worthylake, Christopher T. Sullivan, Thomas R. Ward, Hailly E. Butler, Nancy A. Kramer, Beate Albrecht, Christine M. Armour, Linlea Armstrong, Oana Caluseriu, Cheryl Cytrynbaum, Beth A. Drolet, A. Micheil Innes, Julie L. Lauzon, Angela E. Lin, Grazia M. S. Mancini, Wendy S. Meschino, James D. Reggin, Anand K. Saggar, Tally Lerman-Sagie, Gökhan Uyanik, Rosanna Weksberg, Birgit Zirn, Chandree L. Beaulieu, FORGE Canada Consortium, Jacek Majewski, Dennis E. Bulman, Mark O’Driscoll, Jay Shendure, John M. Graham, Jr., Kym M. Boycott, William B. Dobyns
Nat Genet. Author manuscript; available in PMC 2013 Feb 1.
Published in final edited form as: Nat Genet. 2012 Aug; 44(8): 934–940. Published online 2012 Jun 24. doi: 10.1038/ng.2331
PMCID:
PMC3408813
AbstractArticlePDF–816K
4.
Initial characterization of the human central proteome
Thomas R Burkard, Melanie Planyavsky, Ines Kaupe, Florian P Breitwieser, Tilmann Bürckstümmer, Keiryn L Bennett, Giulio Superti-Furga, Jacques Colinge
BMC Syst Biol. 2011; 5: 17. Published online 2011 Jan 26. doi: 10.1186/1752-0509-5-17
PMCID:
PMC3039570
AbstractArticlePDF–2.3M
5.
The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation
Wei-Lei Yang, Jing Wang, Chia-Hsin Chan, Szu-Wei Lee, Alejandro D. Campos, Lana Hur, Brian Grabiner, Xin Lin, Bryant G. Darnay, Hui-Kuan Lin
Science. Author manuscript; available in PMC 2010 Dec 23.
Published in final edited form as: Science. 2009 Aug 28; 325(5944): 1134–1138. doi: 10.1126/science.1175065
PMCID:
PMC3008763
AbstractArticlePDF–762K
6.
Akt2 and Akt3 play a pivotal role in malignant gliomas
Hideo Mure, Kazuhito Matsuzaki, Keiko T. Kitazato, Yoshifumi Mizobuchi, Kazuyuki Kuwayama, Teruyoshi Kageji, Shinji Nagahiro
Neuro Oncol. 2010 Mar; 12(3): 221–232. Published online 2009 Dec 21. doi: 10.1093/neuonc/nop026
PMCID:
PMC2940586
AbstractArticlePDF–627K
7.
Patterns of somatic mutation in human cancer genomes
Christopher Greenman, Philip Stephens, Raffaella Smith, Gillian L. Dalgliesh, Christopher Hunter, Graham Bignell, Helen Davies, Jon Teague, Adam Butler, Claire Stevens, Sarah Edkins, Sarah O'Meara, Imre Vastrik, Esther E. Schmidt, Tim Avis, Syd Barthorpe, Gurpreet Bhamra, Gemma Buck, Bhudipa Choudhury, Jody Clements, Jennifer Cole, Ed Dicks, Simon Forbes, Kris Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jon Hinton, Andy Jenkinson, David Jones, Andy Menzies, Tatiana Mironenko, Janet Perry, Keiran Raine, Dave Richardson, Rebecca Shepherd, Alexandra Small, Calli Tofts, Jennifer Varian, Tony Webb, Sofie West, Sara Widaa, Andy Yates, Daniel P. Cahill, David N. Louis, Peter Goldstraw, Andrew G. Nicholson, Francis Brasseur, Leendert Looijenga, Barbara L. Weber, Yoke-Eng Chiew, Anna deFazio, Mel F. Greaves, Anthony R. Green, Peter Campbell, Ewan Birney, Douglas F. Easton, Georgia Chenevix-Trench, Min-Han Tan, Sok Kean Khoo, Bin Tean Teh, Siu Tsan Yuen, Suet Yi Leung, Richard Wooster, P. Andrew Futreal, Michael R. Stratton
Nature. Author manuscript; available in PMC 2009 Jul 20.
Published in final edited form as: Nature. 2007 Mar 8; 446(7132): 153–158. doi: 10.1038/nature05610
PMCID:
PMC2712719
AbstractArticlePDF–867K
8.
A novel AKT3 mutation in melanoma tumours and cell lines
M A Davies, K Stemke-Hale, C Tellez, T L Calderone, W Deng, V G Prieto, A J F Lazar, J E Gershenwald, G B Mills
Br J Cancer. 2008 Oct 21; 99(8): 1265–1268. Published online 2008 Sep 23. doi: 10.1038/sj.bjc.6604637
PMCID:
PMC2570525
AbstractArticlePDF–129K
9.
VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase
Gary L. Wright, Ioanna G. Maroulakou, Juanita Eldridge, Tiera L. Liby, Vijayalakshmi Sridharan, Philip N. Tsichlis, Robin C. Muise-Helmericks
FASEB J. 2008 Sep; 22(9): 3264–3275. doi: 10.1096/fj.08-106468
PMCID:
PMC2518259
AbstractArticle
10.
Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha.
K S Walker, M Deak, A Paterson, K Hudson, P Cohen, D R Alessi
Biochem J. 1998 Apr 1; 331(Pt 1): 299–308. doi: 10.1042/bj3310299
PMCID:
PMC1219352
SummaryPDF–823K
11.
The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)
Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504
Correction in:
Genome Res. 2006 Jun; 16(6): 804.
PMCID:
PMC528928
AbstractArticlePDF–140K
12.
Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs
Stefan Wiemann, Bernd Weil, Ruth Wellenreuther, Johannes Gassenhuber, Sabine Glassl, Wilhelm Ansorge, Michael Böcher, Helmut Blöcker, Stefan Bauersachs, Helmut Blum, Jürgen Lauber, Andreas Düsterhöft, Andreas Beyer, Karl Köhrer, Normann Strack, Hans-Werner Mewes, Birgit Ottenwälder, Brigitte Obermaier, Jens Tampe, Dagmar Heubner, Rolf Wambutt, Bernhard Korn, Michaela Klein, Annemarie Poustka
Genome Res. 2001 Mar; 11(3): 422–435. doi: 10.1101/gr.154701
PMCID:
PMC311072
AbstractArticlePDF–542K
13.
Identification of Akt Association and Oligomerization Domains of the Akt Kinase Coactivator TCL1
Gerald Künstle, Jarmo Laine, Gaelle Pierron, Shin-ichiro Kagami, Hiroshi Nakajima, Francois Hoh, Christian Roumestand, Marc-Henri Stern, Masayuki Noguchi
Mol Cell Biol. 2002 Mar; 22(5): 1513–1525. doi: 10.1128/mcb.22.5.1513-1525.2002
PMCID:
PMC134690
AbstractArticlePDF–1.1M
14.
Administration of a Postbiotic Causes Immunomodulatory Responses in Broiler Gut and Reduces Disease Pathogenesis Following Challenge
Casey N. Johnson, Michael H. Kogut, Kenneth Genovese, Haiqi He, Steve Kazemi, Ryan J. Arsenault
Microorganisms. 2019 Aug; 7(8): 268. Published online 2019 Aug 17. doi: 10.3390/microorganisms7080268
PMCID:
PMC6723925
AbstractArticlePDF–1.8M
15.
Retinal Protection and Distribution of Curcumin in Vitro and in Vivo
Chiara B. M. Platania, Annamaria Fidilio, Francesca Lazzara, Cateno Piazza, Federica Geraci, Giovanni Giurdanella, Gian Marco Leggio, Salvatore Salomone, Filippo Drago, Claudio Bucolo
Front Pharmacol. 2018; 9: 670. Published online 2018 Jun 22. doi: 10.3389/fphar.2018.00670
PMCID:
PMC6036289
AbstractArticlePDF–2.0M
16.
A census of P. longum’s phytochemicals and their network pharmacological evaluation for identifying novel drug-like molecules against various diseases, with a special focus on neurological disorders
Neha Choudhary, Vikram Singh
PLoS One. 2018; 13(1): e0191006. Published online 2018 Jan 10. doi: 10.1371/journal.pone.0191006
PMCID:
PMC5761900
AbstractArticlePDF–13M
17.
A Genome-Wide Association Study and Complex Network Identify Four Core Hub Genes in Bipolar Disorder
Zengyan Xie, Xianyan Yang, Xiaoya Deng, Mingyue Ma, Kunxian Shu
Int J Mol Sci. 2017 Dec; 18(12): 2763. Published online 2017 Dec 19. doi: 10.3390/ijms18122763
PMCID:
PMC5751362
AbstractArticlePDF–3.1M
18.
Identification of a RAC/AKT-like gene in Leishmania parasites as a putative therapeutic target in leishmaniasis
Rubén E. Varela-M, Rodrigo Ochoa, Carlos E. Muskus, Antonio Muro, Faustino Mollinedo
Parasit Vectors. 2017; 10: 458. Published online 2017 Oct 10. doi: 10.1186/s13071-017-2379-y
PMCID:
PMC5633885
AbstractArticlePDF–1.4M
19.
Data in support of a harmine-derived beta-carboline in vitro effects in cancer cells through protein synthesis
Annelise Carvalho, Jennifer Chu, Céline Meinguet, Robert Kiss, Guy Vandenbussche, Bernard Masereel, Johan Wouters, Alexander Kornienko, Jerry Pelletier, Véronique Mathieu
Data Brief. 2017 Jun; 12: 546–551. Published online 2017 May 5. doi: 10.1016/j.dib.2017.05.006
PMCID:
PMC5429240
AbstractArticlePDF–293K
20.
Unfoldomics of prostate cancer: on the abundance and roles of intrinsically disordered proteins in prostate cancer
Kevin S Landau, Insung Na, Ryan O Schenck, Vladimir N Uversky
Asian J Androl. 2016 Sep-Oct; 18(5): 662–672. Published online 2016 Jul 19. doi: 10.4103/1008-682X.184999
PMCID:
PMC5000786
AbstractArticlePDF–4.0M

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